Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 2, Issue 3, pp 233–238 | Cite as

Surgical resection for hilar cholangiocarcinoma

  • Russell W. Strong
  • Stephen V. Lynch
Topics

Abstract

A retrospective analysis of 62 patients who underwent resection for hilar cholangiocarcinoma performed between 1981–1994 was undertaken. Type I lesions and patients whose operations were performed less than 24 months prior to analysis were excluded, leaving a study cohort of 48 patients (27 male: 21 female, median age 66 years, range 23–86 years). Median post-operative stay was 20 days (8–60) with peri-operative mortality of 10.4%. Histopathological grading of paraffin sections of excised tumours was made, using standard criteria, into poor, moderate, and well differentiated lesions, and the three sub-groups were separately analysed. Patients with poorly differentiated lesions (n=16) had a median survival of 7 months (range 0–24), with 1-and 2-year survival of 19% and 0%, respectively. The median survival of patients with moderately differentiated tumours (n=20) was 27 months (range 0–84), with 1-, 2-, 3-, and 5-year survival of 70%, 55%, 35%, and 22%, respectively. Those with well differentiated carcinomas (n=12) fared better, with a median survival of 62 months (range 16–120) and 1-, 2-, 3-, and 5-year survival of 100%, 66%, 66%, and 58%, respectively. Differences in survival were highly significant atP<0.0001. Patients with poorly differentiated tumours would be best served by non-surgical intervention if this differentiation could be reliably made pre-operatively. Conversely, those with more favourable histological grading are potentially curable by an aggressive radical resection.

Key words

hilar cholangiocarcinoma high bile duct cancer resection 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Russell W. Strong
    • 1
  • Stephen V. Lynch
    • 1
  1. 1.Department of Surgery, University of QueenslandPrincess Alexandra HospitalBrisbaneAustralia

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