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Medical and Biological Engineering and Computing

, Volume 40, Issue 6, pp 647–649 | Cite as

Accuracy of an optically isolated tetra-polar impedance measurement system

  • S. Nebuya
  • M. Noshiro
  • B. H. Brown
  • R. H. Smallwood
  • P. Milnes
Technical Note

Abstract

Accurate electrical transfer impedance measurement at the high frequencies (>1 MHz) required to characterise blood and intracellular structures is very difficult, owing to stray capacitances between lead wires. To solve this problem, an optically isolated measurement system has been developed using a phaselocked-loop technique for synchronisation between current injection (drive) and voltage measurement (receive) circuits. The synchronisation error between drive and receive circuits was less than 1 ns. The accuracy and reproducibility of the developed system was examined using a tissue equivalent Cole model consisting of two resistors and one capacitor. The absolute value Z and phase shift θ in impedance of the Cole model was measured at 1.25 MHz by both an LCR meter and the isolated measurement system. The difference between the values measured by the isolated measurement system and those measured by the LCR meter was less than 0.27 Ω (2.9%) in Z and 0.79 degree in θ. The standard deviation was less than 0.09Ω in Z and 0.60 degree in θ.

Keywords

Impedance measurement Biological tissue Stray capacitance Optical isolation Phase locked loop 

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Copyright information

© IFMBE 2002

Authors and Affiliations

  • S. Nebuya
    • 1
  • M. Noshiro
    • 1
  • B. H. Brown
    • 2
  • R. H. Smallwood
    • 2
  • P. Milnes
    • 2
  1. 1.Department of Clinical Engineering, School of Allied Health SciencesKitasato UniversityKanagawaJapan
  2. 2.Medical Physics & Engineering, University of SheffieldRoyal Hallamshire HospitalSheffieldUK

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