Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy

  • B. Chevallay
  • D. Herbage
Cellular Engineering: Tissue Engineering and Biomaterials


Many substances are used in the production of biomaterials: metals (titanium), ceramics (alumina), synthetic polymers (polyurethanes, silicones, polyglycolic acid (PGA), polylactic acid (PLA), copolymers of lactic and glycolic acids (PLGA), polyanhydrides, polyorthoesters) and natural polymers (chitosan, glycosaminoglycans, collagen). With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds and cell transplant devices. The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy through the formation of neo-organs or organoids.


Biomaterials Collagen Tissue engineering Gene therapy 


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© IFMBE 2000

Authors and Affiliations

  1. 1.Institut de Biologie et Chimie des ProtéinesUPR 412 CNRSLyonFrance

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