Guillain-Barré polyradiculoneuritis after blood transfusion

  • Merelli E. 
  • Sola P. 
  • Spina I. La 
  • Orlando A. 
  • Milanti G. 
Case Reports

Abstract

We report the case of a 72 year-old woman who developed acute polyradiculoneuritis 7 days after a series of 4 blood transfusion. While blood transfusion is not listed as an antedecent event of Guillain-Barré syndrome (GBS), GBS following surgical procedures is well known. In the present case the close temporal relationship and the absence of all factors which usually precede the onset of the disease including surgery, suggest a possible role of blood transfusion in the onset of the GBS.

Key-words

Guillain-Barré syndrome blood transfusion autoimmune reaction 

Sommario

Viene riportato il caso di una donna di 72 anni, che ha sviluppato una poliradiculopatia acuta 7 giorni dopo essere stata sottoposta a 4 trasfusioni di sangue. Mentre la trasfusione ematica non è compresa tra gli eventi che possono precedere una sindrome di Guillain-Barré (SGB), è nota invece la SGB successiva ad interventi chirurgici. Nel caso descritto la stretta relazione temporale e l'assenza di tutti i fattori di rischio che di solito precedono l'insorgenza della malattia, inclusi gli interventi chirurgici, suggeriscono il possibile ruolo delle trasfusioni ematiche nell'insorgenza della SGB.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Arnason B.G.W.:Acute inflammatory demyelinating polyradiculopathy. In Dyck P.J., Thomas P.K. and Lambert E.M. (eds.). Peripheral Neuropathy, Philadelphia-London-Toronto, WB Saunders, pp. 2050–2100, 1982.Google Scholar
  2. [2]
    Arnason B.G.W., Asbury A.K.:Idiopathic polyneuritis after surgery. Arch. Neurol. 18:500–507, 1968.PubMedGoogle Scholar
  3. [3]
    Asbury A.K.:Diagnostic consideration in Guillain-Barré syndrome. Ann. Neurol. 9 (Suppl): 1–5 1981.PubMedGoogle Scholar
  4. [4]
    Cook S.D., Dowling P.C., Blumberg B.M.:Infection and autoimmunity in the Guillain-Barré syndrome. Clinical Neuroimmunology. Blackwell Scientific Publications, pp. 222–244, 1987.Google Scholar
  5. [5]
    Costantino T., Weintraub A.:The Guillain-Barré syndrome as a complication of the post-perfusion syndrome. Am. Heart. J. 84:678–680, 1972.CrossRefPubMedGoogle Scholar
  6. [6]
    Dowling P., Cook S.:Role of infection in Guillain-Barré syndrome: laboratory confirmation of herpes viruses in 41 cases. Ann. Neurol. 9 (Suppl): 44–55, 1981.PubMedGoogle Scholar
  7. [7]
    Foster K.M., Jack I.:Case report: isolation of cytomegalovirus from blood leukocytes of patient with post-perfusion mononucleosis. Australasian Ann. Med. 17:135–140, 1968.Google Scholar
  8. [8]
    Grose C., Henle W., Henle G., Feorino P.M.:Primary Epstein-Barr virus infection in acute neurologic disease. New Eng. J. Med. 292–392–395, 1972.Google Scholar
  9. [9]
    Hurvitz E.S., Holman R.C., Nelson D.B., Schonberger L.B.:National surveillance for Guillain-Barré syndrome: January 1978 – March 1979. Neurology 33:150–157, 1983.Google Scholar
  10. [10]
    Kaariainen L., Klemola E., Paloheimo J.:Rise of cytomegalovirus antibodies in an infectious mononucleosis-like syndrome after transfusion. Brit. Med. J. 1: 1270–1272, 1966.Google Scholar
  11. [11]
    Steiner I., Argov Z., Cahan C., Abramsky O.:Guillain-Barré syndrome after epidural anesthesia: direct nerve root damage may trigger disease. Neurology 35: 1473–1475, 1985.PubMedGoogle Scholar

Copyright information

© Masson Italia Editori 1991

Authors and Affiliations

  • Merelli E. 
    • 1
  • Sola P. 
    • 1
  • Spina I. La 
    • 1
  • Orlando A. 
    • 1
  • Milanti G. 
    • 2
  1. 1.Clinica NeurologicaUniversità di ModenaModena
  2. 2.Centro di Immunoematologia e TrasfusionaleUniversità di ModenaModenaItaly

Personalised recommendations