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Pharmaceutisch Weekblad

, Volume 5, Issue 5, pp 222–227 | Cite as

Transport in QSAR VIII

The influence of viscosity on transport rate constants in two-phase systems organic solvent-water
  • F. H. N. de Haan
  • A. C. A. Jansen
Original Articles
  • 14 Downloads

Abstract

In the system cyclohexane-water transport rate constants and partition coefficients of nine sulfonamides are determined at six temperatures. Kinematic viscosities of the organic and aqueous layer are determined at the same temperatures. Experimentally bilinear relationships between transport rate constants and partition coefficients are obtained in good agreement with theory. According to this theory convection and diffusion are important features in the overall transport process. Using the experimental data, the influence of viscosity on transport rate constants is established and expressed in terms of the relationships between maximum transport rate constants and viscosities. These relationships correspond with laminar flow at both sides of the interface.

Keywords

Public Health Sulfonamide Experimental Data Internal Medicine Partition Coefficient 
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Copyright information

© Bohn, Scheltema & Holkema 1983

Authors and Affiliations

  • F. H. N. de Haan
    • 1
  • A. C. A. Jansen
    • 1
  1. 1.Department of Pharmacochemistry, Subfaculty of PharmacyUniversity of LeidenRA LeidenThe Netherlands

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