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Pharmaceutisch Weekblad

, Volume 5, Issue 5, pp 210–212 | Cite as

The bioavailability of two new preparations of spironolactone tablets

  • A. J. Nijkerk
  • J. M. Vermeer
  • M. Imanse
  • D. de Vos
Original Articles
  • 49 Downloads

Abstract

Two new preparations of spironolactone tablets containing 25 and 100 mg of spironolactone have been characterized by their disintegration time, tablet spironolactone content, dissolution profile and bioavailability in comparison with two known spironolactone preparations as reference material. The preparations were found to possess almost identical characteristics, assuring a proper clinical use of the new tablet preparations. For spironolactone, a positive outcome of thein vitro dissolution test coincides with an excellent bioavailability.

Keywords

Public Health Internal Medicine Assure Positive Outcome Reference Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1983

Authors and Affiliations

  • A. J. Nijkerk
    • 1
  • J. M. Vermeer
    • 1
  • M. Imanse
    • 1
  • D. de Vos
    • 1
    • 2
  1. 1.Pharmachemie BVCP HaarlemThe Netherlands
  2. 2.Department of PharmacologySylvius LaboratoriesAL LeidenThe Netherlands

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