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Pharmaceutisch Weekblad

, Volume 5, Issue 5, pp 197–204 | Cite as

Inhibitors of the angiotensin I converting enzyme as antihypertensive drugs

  • P. A. van Zwieten
  • A. de Jonge
  • P. B. M. W. M. Timmermans
Review Articles
  • 23 Downloads

Abstract

Inhibitors of the angiotensin I converting enzyme (captopril, enalapril) offer a new principle in the drug treatment of hypertension and congestive heart failure. The present survey deals with the mode of action of the converting enzyme inhibitors, including possible interference with the renin-angiotensin systems in the kidney, the vascular wall and the brain, with the kallikreine-bradykinine system and with the sympathetic nervous system, at both pre- and postjunctional sites. Furthermore, the haemodynamic pattern as well as the therapeutic applications are discussed, including the most important sideeffects, contra-indications, interactions and clinical pharmacokinetic properties.

Keywords

Hypertension Heart Failure Nervous System Angiotensin Congestive Heart Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1983

Authors and Affiliations

  • P. A. van Zwieten
    • 1
  • A. de Jonge
    • 1
  • P. B. M. W. M. Timmermans
    • 1
  1. 1.Division of PharmacotherapyUniversity of AmsterdamTV AmsterdamThe Netherlands

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