Estimating a worker entry interval for the carbamate pesticide Furadan 4F insecticide

  • William F. Serat
Article
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Abstract

Existing methods for the calculation of worker entry intervals by the use of kinetic data have focused on the anticholinesteratic organic phosphates. As carbamate pesticides share with these materials a common site for inhibition, the kinetic method was applied in estimating an entry interval for the carbamate, carbofuran, applied to citrus and grapes as Furadan 4F. No allowance was made for the more transient carbamylation of cholinesterase attributed toN-methyl carbamates, compared with the phosphorylation of the enzyme by organic phosphates. Thus, a measure of safety was built into the calculations which can then be used to establish safe reentry intervals to insure residue levels below the physiological threshold for cholinesterase inhibition.

Keywords

Enzyme Phosphate Cholinesterase Carbamate Kinetic Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Corbett, J. R.: The biochemical mode of action of pesticides. Acad. Press, New York, p. 141 (1974).Google Scholar
  2. FMC: Agricultural Chemical Division, FMC Corporation, Middleport, N.Y. (1976).Google Scholar
  3. Gaines, T. B.: Acute toxicity of pesticides. Toxicol. Appl. Pharmacol.14, 515 (1969a).CrossRefGoogle Scholar
  4. Gaines, T. B.: Unpublished communication (1969b).Google Scholar
  5. Grob, D., and A. M. Harvey: Observation on the effects of tetraethylpyrophosphate in man, and its use in the treatment of myasthenia gravis. Johns Hopkins Hosp. Bull.84, 532 (1949).Google Scholar
  6. Grob, D., and A. M. Harvey: Effects in man of the anticholinesterase compound sarin (isopropylmethyl phosphonofluoridate). J. Clin. Invest.37, 350 (1958).Google Scholar
  7. Grob, D., J. L. Lilienthal, Jr., A. M. Harvey, and B. F. Jones: The administration of diisopropyl fluorophosphate (DFP) to man I. Effect on plasma and erythrocyte cholinesterases, general systemic effects, use in study of hepatic function and erythropoiesis and some properties of plasma cholinesterase. Johns Hopkins Hosp. Bull.81, 217 (1947).Google Scholar
  8. Gunther, F. A., W. E. Westlake, J. H. Barkeley, W. Winterlin, and L. Langbehn: Establishing dislodgable pesticide residues on leaf surfaces. Bull. Environ. Contam. Toxicol.9, 243 (1973).CrossRefGoogle Scholar
  9. Guthrie, F. E., J. J. Domanski, A. L. Chasson, D. E. Bradway, and R. J. Monroe: Human subject experiments to estimate reentry periods for microcrotophos-treated tobacco. Arch. Environ. Contam. Toxicol.4, 217 (1976).CrossRefGoogle Scholar
  10. O'Brien, R. D.: Insecticides-action and metabolism. Acad. Press, New York, p. 89 (1967).Google Scholar
  11. Serat, W. F.: Calculation of a safe reentry time into an orchard treated with a pesticide chemical which produces a measurable physiological response. Arch. Environ. Contam. Toxicol.1, 170 (1973).Google Scholar
  12. Serat, W. F., and J. B. Bailey: Estimating the relative toxicologic potential of each pesticide in a mixture of residues on foliage. Bull. Environ. Contam. Toxicol.12, 682 (1974).CrossRefGoogle Scholar
  13. Serat, W. F., D. C. Mengle, H. P. Anderson, E. Kahn, and J. B. Bailey: On the estimation of worker entry intervals into pesticide treated fields with and without the exposure of human subjects. Bull. Environ. Contam. Toxicol.13, 506 (1975).CrossRefGoogle Scholar
  14. Ware, G. W., D. P. Morgan, B. J. Estesen, W. P. Cahill, and D. M. Whitacre: Establishment of reentry intervals for organophosphate-treated cotton fields based on human data. I. Ethyl- and methyl-parathion. Arch. Environ. Contam. Toxicol.1, 48 (1973).CrossRefGoogle Scholar
  15. Ware, G. W., D. P. Morgan, B. J. Estesen, and W. P. Cahill: Establighment of reentry intervals for organophosphate-treated cotton fields based on human data II. Azodrin, ethyl-and methyl-parathion. Arch Environ. Contam. Toxicol.2, 117 (1974).CrossRefGoogle Scholar
  16. Ware, G. W., D. P. Morgan, B. J. Estesen, and W. P. Cahill: Establishment of reentry intervals for organophosphate-treated cotton fields based on human data III. Twelve to 72 hours post-treatment exposure to monocrotophos, ethyl-and methyl-parathion. Arch. Environ. Contam. Toxicol.3, 289 (1975).CrossRefGoogle Scholar
  17. Wolfe, H. R., J. W. Armstrong, D. C. Staiff, S. W. Comer, and W. F. Durham: Exposure of apple thinners to parathion residues. Arch. Environ. Contam. Toxicol.3, 257 (1975).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc 1978

Authors and Affiliations

  • William F. Serat
    • 1
  1. 1.Community Studies on PesticidesState Department of HealthBerkeley

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