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Chromatographia

, Volume 30, Issue 7–8, pp 357–360 | Cite as

Sub PPB level determination of eperison in human plasma by GC/MS

  • A. Cappiello
  • F. Mangani
  • P. Palma
  • E. Sisti
  • F. Bruner
Originals

Summary

Very low concentrations (down to 0.2 ng/mL) of an antispasmodic drug (Eperison) can be extracted from human plasma and analyzed by GC/MS. For sample preparation and preconcentration, solid phase extraction (SPE) has been employed. A double focussing mass spectrometer was interfaced with a capillary GC column for the GC/MS analysis. The gas chromatograph was equipped with an on-column injector to avoid thermal decomposition.

Key Words

Gas chromatography mass spectrometry Solid phase extraction Eperison in Human plasma Trace determination 

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References

  1. [1]
    M. Kinter, S. Singh, R. A. Felder, J. Chromatogr.496, 201 (1989).Google Scholar
  2. [2]
    K. E. Brooks, N. B. Smith, Clin. Chem.35, 2100 (1989).Google Scholar
  3. [3]
    J. D. Kokanovich, T. F. Simonick, V. W. Watts, J. High Resolut. Chromatogr.12, 45 (1989).CrossRefGoogle Scholar
  4. [4]
    G. M. Rodchenkov, V. P. Uralets, V. A. Semenov, P. A. Leclercq, J. High Resolut. Chromatogr.11, 283 (1988).CrossRefGoogle Scholar
  5. [5]
    F. Mangani, G. Crescentini, P. Palma, F. Bruner, J. Chromatogr.452, 527 (1988).CrossRefGoogle Scholar
  6. [6]
    F. Mangani, G. Crescentini, F. Bruner, Anal. Chem.55, 793 (1983).CrossRefGoogle Scholar
  7. [7]
    F. Mangani, F. Bruner, Chromatographia17, 377 (1983).CrossRefGoogle Scholar
  8. [8]
    F. Bruner, G. Bertoni, G. Crescentini, J. Chromatogr.167, 399 (1978).Google Scholar
  9. [9]
    F. Andreolini, A. di Corcia, A. Laganà, R. Samperi, Clin. Chem.310, 208 (1983).Google Scholar
  10. [10]
    F. Andreolini, C. Borra, A. di Corcia, R. Samperi, J. Chromatogr.310, 208 (1984).Google Scholar
  11. [11]
    Halvor Jaeger (Editor), “Capillary Gas Chromatography-Mass Spectrometry in Medicine and Pharmacology”, Hüthig, Heidelberg, FRG, 1987.Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1990

Authors and Affiliations

  • A. Cappiello
    • 1
  • F. Mangani
    • 1
  • P. Palma
    • 1
  • E. Sisti
    • 1
  • F. Bruner
    • 1
  1. 1.Istituto di Scienze ChimicheUniversità di UrbinoUrbinoItaly

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