Journal of Neuro-Oncology

, Volume 6, Issue 2, pp 107–112 | Cite as

Whole brain irradiation and intrathecal Methotrexate in the treatment of solid tumor leptomeningeal metastases — A Southwest Oncology Group study

  • William T. Sause
  • John Crowley
  • Harmon J. Eyre
  • Saul E. Rivkin
  • Reginald P. Pugh
  • Joseph M. Quagliana
  • Sarah A. Taylor
  • Beverly Molnar


From 1981 through 1985 the Southwest Oncology Group (SWOG) conducted a study evaluating the natural history and the effectiveness of standard therapy in those patients with leptomeningeal carcinomatosis from non-hematologic malignancies. Twenty-six patients were evaluated for the effectiveness of treatment; those who responded to therapy by one month exhibited a median additional survival of 5.7 months and those who were not responders at one month exhibited a median additional survival of 1.8 months. We were unable to identify pre-treatment clinical characteristics which would predict for a favorable response to therapy. Aggressive treatment in some patients may be indicated, as those patients who respond to treatment may have a survival benefit. The overall prognosis in this patient group remains exceedingly poor.

Key words

leptomeningeal carcinomatosis intrathecal methotrexate whole brain irradiation 


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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • William T. Sause
    • 1
  • John Crowley
    • 2
  • Harmon J. Eyre
    • 1
  • Saul E. Rivkin
    • 3
  • Reginald P. Pugh
    • 4
  • Joseph M. Quagliana
    • 5
  • Sarah A. Taylor
    • 6
  • Beverly Molnar
    • 1
  1. 1.University of Utah Medical CenterSeattle
  2. 2.Southwest Oncology Group Statistical CenterSeattle
  3. 3.Puget Sound Oncology ConsortiumKansas CityUSA
  4. 4.Allegheny Health, Education & ResearchKansas CityUSA
  5. 5.Humana Hospital SunriseKansas CityUSA
  6. 6.Veterans Administration HospitalKansas CityUSA

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