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Pharmaceutisch Weekblad

, Volume 7, Issue 5, pp 186–193 | Cite as

Studies on tableting properties of lactose

Part 2. Consolidation and compaction of different types of crystalline lactose
  • H. Vromans
  • A. H. De Boer
  • G. K. Bolhuis
  • C. F. Lerk
  • K. D. Kussendrager
  • H. Bosch
Original Articles

Abstract

Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on the degree of fragmentation only. This finding indicates that the nature of the actual binding must be the same for the different types of crystalline lactose.

Keywords

Public Health Internal Medicine Mercury Lactose Actual Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • H. Vromans
    • 1
  • A. H. De Boer
    • 1
  • G. K. Bolhuis
    • 1
  • C. F. Lerk
    • 1
  • K. D. Kussendrager
    • 2
  • H. Bosch
    • 3
  1. 1.Laboratory for Pharmaceutical Technology and DispensingAW GroningenThe Netherlands
  2. 2.DMVBA VeghelThe Netherlands
  3. 3.Department of Chemical TechnologyTwente University of TechnologyAE EnschedeThe Netherlands

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