Pharmaceutisch Weekblad

, Volume 7, Issue 5, pp 173–180 | Cite as

Cisplatin: Synthesis, antitumour activity and mechanism of action

  • J. Reedijk
  • P. H. M. Lohman
Review Articles


A review is presented on the successful antitumour drugcis-diamminedichloroplatinum(II), better known as cisplatin. Special attention is given to the synthesis of the compound and related derivatives, and to the nature of the hydrolysis products in blood and in the cell. In the second part of the review the mechanism of action is discussed. Binding to DNA and in particular the formation of intrastrand cross-links between adjacent guanines, to which the Pt(NH3)22+ ion is chelated at the N7 atoms, seems to be a very important event. However, at the moment it is not yet known which DNA lesion is responsible for the killing of the tumour cells.


Public Health Tumour Cell Internal Medicine Guanine Hydrolysis Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • J. Reedijk
    • 1
  • P. H. M. Lohman
    • 2
  1. 1.Department of Chemistry, Gorlaeus LaboratoriesState University of LeidenRA LeidenThe Netherlands
  2. 2.Medical Biological Laboratory TNOAA RijswijkThe Netherlands

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