Corneal epithelial dysplasia after trifluridine use

  • P. C. Maudgal
  • B. Van Damme
  • L. Missotten


Prolonged topical trifluridine treatment of herpes simplex keratitis in three elderly patients produced slightly raised dysplastic corneal epithelial lesions. The involved epithelium had a ground-glass appearance and exhibited opaque cells, edema, and spindle-shaped surface cells. Histopathology demonstrated severe cellular atypism, loss of cell polarity, dyskeratosis, parakeratosis, and a few mitotic figures. The pathological change was apparently intraepithelial. After scraping, the edema and opaque cells in the regenerated epithelium gradually disappeared in 3–4 months on cessation of trifluridine therapy. In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided.


Herpes Simplex Precancerous Condition Cell Polarity Keratitis Mitotic Figure 
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Copyright information

© Springer-Verlag GmBH & Co. KG, Berlin Heidelberg 1983

Authors and Affiliations

  • P. C. Maudgal
    • 1
  • B. Van Damme
    • 2
  • L. Missotten
    • 1
  1. 1.Eye Research Laboratory of the Ophthalmology ClinicUniversity of LeuvenLeuvenBelgium
  2. 2.Pathology DepartmentUniversity of LeuvenLeuvenBelgium

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