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Annals of Surgical Oncology

, Volume 2, Issue 5, pp 429–434 | Cite as

Estrogen and progesterone receptors in thyroid lesions

  • Beth R. Jaklic
  • Jeanne Rushin
  • Bimal C. Ghosh
Original Articles

Abstract

Background: Given the higher incidence and better prognosis of thyroid cancers in women, the possibility arises that these lesions may be influenced by sex hormones. With the development of monoclonal antibodies to the estrogen and progesterone receptor proteins, receptor status can now be determined by immunohistochemical methods that allow direct localization of receptors in tissue.

Methods: Using this technique, we have studied tissues of 11 patients, 2 of them pregnant, with thyroid lesions. Paraffin-embedded tissues were used. Positive controls consisted of known estrogen- and progesterone-positive breast carcinomas.

Results: Examination of both the thyroid lesions and adjacent uninvolved thyroid tissue showed no nuclear reactivity with either estrogen or progesterone receptor antibodies. Our study did not confirm the previously reported incidence of estrogen and progesterone receptors in thyroid lesions.

Conclusions: We conclude that contrary to earlier indications, estrogen and progesterone receptor proteins are neither significantly detectable nor pertinent for follow-up or prognosis in the patient with thyroid neoplasia.

Key Words

Receptors Estrogen receptors Progesterone Thyroid 

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References

  1. 1.
    Henderson BE, Ross RK, Pike MC, Casagrande JT. Endogenous hormones as a major factor in human cancer.Cancer Res 1982;42:3232–9.PubMedGoogle Scholar
  2. 2.
    Stedman KE, Moore GE, Morgan RT. Estrogen receptor proteins in diverse human tumors.Arch Surg 1980;2:244–8.Google Scholar
  3. 3.
    McDermott WV Jr, Morgan WS, Hamlin E Jr, Cope O. Cancer of the thyroid.J Clin Endocrinol Metab 1954;14:1336–54.PubMedGoogle Scholar
  4. 4.
    Sloan WL. Of the origin, characteristics and behavior of thyroid cancer.J Clin Endocrinol Metab 1954;14:1308–35.Google Scholar
  5. 5.
    Cady B, Segwick CE, Meissner WA, Wool MS, Salzman FA, Werber JW. Risk factor analysis in differentiated thyroid cancer.Cancer 1979;43:810–20.PubMedGoogle Scholar
  6. 6.
    Franssila KO. Prognosis in thyroid carcinoma.Cancer 1975;36:1138–46.PubMedGoogle Scholar
  7. 7.
    Molteni A, Warpeha RL, Brizio-Molteni L, Fors EM. Estradiol receptor-binding protein in head and neck neoplastic and normal tissue.Arch Surg 1981;116:207–10.PubMedGoogle Scholar
  8. 8.
    Clark OH, Gerend MA, Davis M, Goretzki PE, Hoffman PG Jr. Estrogen and thyroid-stimulating hormone receptors in neoplastic and nonneoplastic human thyroid tissue.J Surg Res 1985;38:89–96.CrossRefPubMedGoogle Scholar
  9. 9.
    Hampl R, Nemec J, Heresova J, Kimlova I, Starka L. Estrogen receptors in human goitrous and neoplastic thyroid.Endocrinol Exp 1985;19:227–30.PubMedGoogle Scholar
  10. 10.
    Chaudhuri PK, Prinz R. Estrogen receptor in normal and neoplastic human thyroid tissue.Am J Otolaryngol 1989;10:322–6.PubMedGoogle Scholar
  11. 11.
    Miki H, Oshimo K, Inoue H, Morimoto T, Monden Y. Sex hormone receptors in human thyroid tissues.Cancer 1990;66:1759–62.PubMedGoogle Scholar
  12. 12.
    Hiasa Y, Nishioka H, Kitahori Y, Yane K, Nakaoka S, Ohshima M, Konishi N, et al. Immunohistochemical detection of estrogen receptors in paraffin sections of human thyroid tissues.Oncology 1991;48:421–4.PubMedGoogle Scholar
  13. 13.
    Diaz NM, Mazoujian G, Wick M. Estrogen-receptor protein in thyroid neoplasms.Arch Pathol Lab Med 1991;115:1203–7.PubMedGoogle Scholar
  14. 14.
    Cheng L, Binder SW, Fu YS, Lewin KJ. Demonstration of estrogen receptors by monoclonal antibody in formalin-fixed breast tumors.Lab Invest 1988;58:346–53.PubMedGoogle Scholar
  15. 15.
    McGadey J. A tetrazolium method for non-specific alkaline phosphatase.Histochemie 1970;23:180–4.CrossRefPubMedGoogle Scholar
  16. 16.
    Andersen J, Orntoft TF, Poulsen HS. Immunohistochemical demonstration of estrogen receptors (ER) in formalin-fixed, paraffin-embedded human breast cancer tissue by use of a monoclonal antibody to ER.J Histochem Cytochem 1988;36:1553–60.PubMedGoogle Scholar
  17. 17.
    Shintaku IP, Said JW. Detection of estrogen receptors with monoclonal antibodies in routinely processed formalin-fixed paraffin sections of breast carcinoma: use of Dnase pretreatment to enhance sensitivity of the reaction.Am J Clin Pathol 1987;87:161–7.PubMedGoogle Scholar
  18. 18.
    Folca PJ, Glascock RF, Irvine WT. Studies with tritiumlabelled hexoestrol in advanced breast cancer.Lancet 1961;2:796–8.PubMedGoogle Scholar
  19. 19.
    Korenman SS. Radio-ligand binding assay of specific estrogens using a soluble uterine macromolecule.J Clin Endocrinol Metab 1968;28:127–30.PubMedGoogle Scholar
  20. 20.
    Feherty P, Farrer-Brown G, Kellie AE. Oestradiol receptors in carcinoma and benign disease of the breast: an in vitro assay.Br J Cancer 1971;25:697–710.PubMedGoogle Scholar
  21. 21.
    Poulsen HS, Bukh A, Rytter L, Orntoft T, Andersen U, Thomsen K, Moller NPH, et al. Oestrogen receptor assay: false positive analysis?Acta Radiol (Oncol) 1984;23:109–17.Google Scholar
  22. 22.
    Greene GL, Nolan C, Engler JP, Jensen EV. Monoclonal antibodies to human estrogen receptor.Proc Natl Acad Sci USA 1980;77:5115–9.PubMedGoogle Scholar
  23. 23.
    Greene GL, Harris K, Bova R, Kinders R, Moore B, Nolan C. Purification of T47D human progesterone receptor and immunochemical characterization with monoclonal antibodies.Mol Endocrinol 1988;2:714–26.PubMedGoogle Scholar
  24. 24.
    Jonat W, Maas H, Stegner HE. Immunohistochemical measurement of estrogen receptors in breast cancer tissue samples.Cancer Res (Suppl) 1986;46:4296–8s.Google Scholar
  25. 25.
    McCarty KS Jr, Miller LS, Cox EB, Konrath J, McCarty KS Sr. Estrogen receptor analyses: correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies.Arch Pathol Lab Med 1985;109:716–21.PubMedGoogle Scholar
  26. 26.
    Hiort O, Kwan PW, DeLellis RA. Immunohistochemistry of estrogen receptor protein in paraffin sections. Effects of enzymatic pretreatment and cobalt chloride intensification.Am J Clin Pathol 1988;90:559–63.PubMedGoogle Scholar
  27. 27.
    Masood S, Supranee D, Goldstein JD. Immunocytochemical analysis of progesterone receptors in breast cancer.Am J Clin Pathol 1991;96:59–63.PubMedGoogle Scholar

Copyright information

© The Society of Surgical Oncology, Inc 1995

Authors and Affiliations

  • Beth R. Jaklic
    • 3
  • Jeanne Rushin
    • 1
  • Bimal C. Ghosh
    • 2
  1. 1.Department of PathologyNational Naval Medical CenterUSA
  2. 2.Uniformed Services University of Health SciencesBethesdaUSA
  3. 3.Department of SurgeryNational Naval Medical CenterBethesdaUSA

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