Annals of Surgical Oncology

, Volume 5, Issue 3, pp 261–264 | Cite as

Carcinoid tumor of the breast: Treatment with breast conservation in three patients

  • Lisa K. Jablon
  • Robert G. Somers
  • Philip Y. Kim
Original Articles


Background: Carcinoid tumors of the breast have been described in the literature. The diagnosis is made by identification of typical histologic features and confirmed by a positive argyrophilic reaction or the presence of neurosecretory granules. There are several theories of the pathogenesis of carcinoid tumors in the breast and controversy as to whether these tumors actually originate in the breast ducts or are tumors that arise from neuroectodermal cells that have migrated to the breast ducts. Historically, treatment of carcinoid of the breast has been by mastectomy.

Methods: We report three cases of primary carcinoid tumor of the breast treated with lumpectomy and axillary node dissection. No adjuvant radiation or systemic treatment was administered.

Results: In all three cases, no metastases were identified in lymph nodes sampled and all patients have remained clinically free of recurrent disease.

Conclusions: Decisions about the need for radiation or systemic treatment of breast carcinoid tumors depend on one's interpretation of the pathogenesis of this disease. Breast conservation is a surgical option that has not been previously reported. Larger series of carcinoid tumors of the breast, their treatment, and their follow-up are needed.

Key Words

Carcinoid tumor Mammary carcinoid Breast conservation 


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  1. 1.
    Cubilla AL, Woodruff JM. Primary carcinoid tumor to the breast. A report of eight patients.Am J Pathol 1977;1:283–92.Google Scholar
  2. 2.
    Fisher ER, Palekar AS, NSABP Collaborators. Solid and mucinous varieties of so-called mammary carcinoid tumors.Am Soc Clin Pathol 1979;72:911–16.Google Scholar
  3. 3.
    Van Laarhoven HAJ, Gratama S, Wereldsma JCJ. Neuroendocrine carcinoid tumors of the breast: A variant of carcinoma with neuroendocrine differentiation.J Surg Oncol 1991;46:125–32.PubMedGoogle Scholar
  4. 4.
    Lazarevic B, Rodgers JB. Aspiration cytology of carcinoid tumor of the breast. A case report.Acta Cytol 1983;27:329–33.PubMedGoogle Scholar
  5. 5.
    Feyrter F, Hartmann G. Uber die carcinoide wushsform des carcinoma mammae, insbesondere das carcinoma solidum (gelatinosum) mammae.Frandf z Path 1963;73:24–35.Google Scholar
  6. 6.
    Sheehan DC.Theory and practice of histotechnology. 2nd ed. St. Louis: CV Mosby, 1980:256–8.Google Scholar
  7. 7.
    Ferguson DJP, Anderson TJ, Wells CA, Battersby S. An ultrastructural study of mucoid carcinoma of the breast: variability of cytoplasmic features.Histopathology 1986;10:1219–30.PubMedGoogle Scholar
  8. 8.
    Hadju SI, Urban JA. Cancers metastatic to the breast.Cancer 1972;29:1691–6.Google Scholar
  9. 9.
    Beal JM. Lung tumor following mastectomy.Ill Med J 1971;140:208–12.Google Scholar
  10. 10.
    Taxy JB, Tischler AS, Insalaco SJ, Battifora H. “Carcinoid” tumor of the breast. A variant of conventional breast cancer?Human Pathol 1981;12:170–9.Google Scholar
  11. 11.
    Chen KTK. Breast carcinomas with carcinoid features.Breast 1981;7:2–5.Google Scholar
  12. 12.
    Scopsi L, Andreola S, Pilotti S, Baldini MT, Lombardi L, Shimizu F, Hultner WB. Argyrophilia and granin (chromagranin/secretetogranin). Expression in female breast carcinomas.Am J Surg Pathol 1992;16:561–76.PubMedGoogle Scholar
  13. 13.
    Keshgegian AA, Wheeler JE. Estrogen receptor protein in malignant carcinoid tumor.Cancer 1980;45:293–6.PubMedGoogle Scholar

Copyright information

© The Society of Surgical Oncology, Inc. 1998

Authors and Affiliations

  • Lisa K. Jablon
    • 1
  • Robert G. Somers
    • 1
  • Philip Y. Kim
    • 1
  1. 1.Albert Einstein Medical CenterPhiladelphia

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