Annals of Surgical Oncology

, Volume 5, Issue 8, pp 695–698 | Cite as

Long-term survival in patients with ovarian metastases from colorectal carcinoma

  • Peter P. Huang
  • Thomas K. Weber
  • Carlos Mendoza
  • Miguel A. Rodriguez-Bigas
  • Nicholas J. Petrelli
Original Articles


Background: Ovarian metastases (OM) are a relatively uncommon consequence of primary colorectal carcinoma (CRC). The authors present a retrospective review of the impact of elective and therapeutic oophorectomy on the natural history of CRC.

Methods: Patients with primary CRC from January 1964 through March 1996 were reviewed. Survival from the time of OM diagnosis was estimated by the Kaplan-Meier method; differences between groups were based on the log-rank test.

Results: A total of 155 patients were studied. Synchronous OM occurred in 90 patients (58.1%); metachronous OM occurred in 65 patients (41.9%). Estimated 5-year survival for patients with synchronous OM was 9%, versus 20% for metachronous OM (P<.0001). Resection of metastatic disease was associated with an improved 5-year survival for synchronous OM (15% vs. 0%,P=.0001) and metachronous OM (24% vs. 0%,P<.0001) if patients were disease-free postoperatively. Other clinical characteristics, including age, menopausal status, stage, and location of primary tumor, had no significant impact on survival.

Conclusions: Ovarian metastases from colorectal carcinoma are associated with a poor outcome. Although there is no survival advantage associated with resection of occult microscopic disease, long-term survival is possible if patients are rendered surgically disease-free.

Key Words

Colorectal carcinoma Surgery Ovarian Metastases Survival 


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Copyright information

© The Society of Surgical Oncology, Inc. 1998

Authors and Affiliations

  • Peter P. Huang
    • 1
  • Thomas K. Weber
    • 1
  • Carlos Mendoza
    • 1
  • Miguel A. Rodriguez-Bigas
    • 1
  • Nicholas J. Petrelli
    • 1
  1. 1.From the Division of Surgical Oncology, Roswell Park Cancer InstituteState University of New York at BuffaloBuffalo

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