Annals of Surgical Oncology

, Volume 5, Issue 8, pp 695–698 | Cite as

Long-term survival in patients with ovarian metastases from colorectal carcinoma

  • Peter P. Huang
  • Thomas K. Weber
  • Carlos Mendoza
  • Miguel A. Rodriguez-Bigas
  • Nicholas J. Petrelli
Original Articles

Abstract

Background: Ovarian metastases (OM) are a relatively uncommon consequence of primary colorectal carcinoma (CRC). The authors present a retrospective review of the impact of elective and therapeutic oophorectomy on the natural history of CRC.

Methods: Patients with primary CRC from January 1964 through March 1996 were reviewed. Survival from the time of OM diagnosis was estimated by the Kaplan-Meier method; differences between groups were based on the log-rank test.

Results: A total of 155 patients were studied. Synchronous OM occurred in 90 patients (58.1%); metachronous OM occurred in 65 patients (41.9%). Estimated 5-year survival for patients with synchronous OM was 9%, versus 20% for metachronous OM (P<.0001). Resection of metastatic disease was associated with an improved 5-year survival for synchronous OM (15% vs. 0%,P=.0001) and metachronous OM (24% vs. 0%,P<.0001) if patients were disease-free postoperatively. Other clinical characteristics, including age, menopausal status, stage, and location of primary tumor, had no significant impact on survival.

Conclusions: Ovarian metastases from colorectal carcinoma are associated with a poor outcome. Although there is no survival advantage associated with resection of occult microscopic disease, long-term survival is possible if patients are rendered surgically disease-free.

Key Words

Colorectal carcinoma Surgery Ovarian Metastases Survival 

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References

  1. 1.
    Herrera LO, Ledesma EJ, Natarajan N, Lopez GE, Tsukada Y, Mittelman A. Metachronous ovarian metastases from adenocarcinoma of the colon and rectum.Surg Gynecol Obstet 1982:154:531–3.PubMedGoogle Scholar
  2. 2.
    Blamey S, McDermott F, Pihl E, Price AB, Milne BJ, Hughes E. Ovarian involvement in adenocarcinoma of the colon and rectum.Surg Gynecol Obstet 1981;153:42–4.PubMedGoogle Scholar
  3. 3.
    Antoniades K, Spector HB, Hecksher RH. Prophylactic oophorectomy in conjunction with large-bowel resection for cancer: report of two cases.Dis Colon Rectum 1977:20:506–10.PubMedGoogle Scholar
  4. 4.
    Mason MH, Kovalcik PJ. Ovarian metastases from colon cancer.J Surg Oncol 1981:17:33–8.PubMedGoogle Scholar
  5. 5.
    Fleming ID, Cooper JS, Henson ED, eds.AJCC Manual for Staging of Cancer. 5th ed. Philadelphia: Lippincott-Raven, 1997.Google Scholar
  6. 6.
    Kaplan EL, Meier P. Non-parametric estimation from incomplete observations.J Am Statist Assoc 1958:53:457–81.Google Scholar
  7. 7.
    MacKeigan J, Ferguson J. Prophylactic oophorectomy and colorectal cancer in premenopausal patients.Dis Colon Rectum 1979;22:401–5.PubMedGoogle Scholar
  8. 8.
    Mason M, Kovalcik P. Ovarian metastases from colon carcinoma.J Surg Oncol 1981;17:33–8.PubMedGoogle Scholar
  9. 9.
    O'Brien P, Newton B, Metcalf J, et al. Oophorectomy in women with carcinoma of the colon and rectum.Surg Gynecol Obstet 1981;153:827–30.PubMedGoogle Scholar
  10. 10.
    Morrow M, Enker WE. Late ovarian metastases in carcinoma of the colon and rectum.Arch Surg 1984:119:1385–8.PubMedGoogle Scholar
  11. 11.
    Young-Fadok TM, Wolff BG, Nivatvongs S, Metzger PP, Ilstrup DM. Prophylactic oophorectomy in colorectal carcinoma: preliminary results of a randomized, prospective trial.Dis Colon Rectum 1998:41:277–85.PubMedGoogle Scholar
  12. 12.
    Quan SHA, Sehdev M. Pelvic surgery concomitant with bowel resection for carcinoma.Surg Clin North Am 1974:54:881–6.PubMedGoogle Scholar
  13. 13.
    Herrera-Ornelas L, Mittelman A. Results of synchronous surgical removal of primary colorectal adenocarcinoma and ovarian metastases.Oncology 1984:41:96–100.PubMedGoogle Scholar

Copyright information

© The Society of Surgical Oncology, Inc. 1998

Authors and Affiliations

  • Peter P. Huang
    • 1
  • Thomas K. Weber
    • 1
  • Carlos Mendoza
    • 1
  • Miguel A. Rodriguez-Bigas
    • 1
  • Nicholas J. Petrelli
    • 1
  1. 1.From the Division of Surgical Oncology, Roswell Park Cancer InstituteState University of New York at BuffaloBuffalo

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