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Digestive Diseases and Sciences

, Volume 39, Supplement 12, pp 104S–106S | Cite as

[*C]Octanoic acid breath test to measure gastric emptying rate of solids

  • B. D. Maes
  • Y. F. Ghoos
  • P. J. Rutgeerts
  • M. I. Hiele
  • B. Geypens
  • G. Vantrappen
Section IV: Methods To Study Gastric Emptying

Abstract

We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid.In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by simultaneous radioscintigraphic and breath test measurements. Nine healthy volunteers were studied after intravenous administration of 200 mg erythromycin and peroral administration of 30 mg propantheline, respectively. Erythromycin significantly enhanced gastric emptying, while propantheline significantly reduced gastric emptying rates. We conclude that the [*C]octanoic breath test is a promising and reliable test for measuring the gastric emptying rate of solids.

Key words

gastric emptying solids breath test octanoic acid 

References

  1. 1.
    Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, Vantrappen G: Measurement of gastric emptying rate of solids by means of a carbon-labelled octanoic acid breath test. Gastroenterol 104:1640–1647, 1993Google Scholar
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    Maes BD, Hiele MI, Geypens BJ, Rutgeerts PJ, Ghoos YF, Vantrappen G: Pharmacological modulation of gastric emptying rate of solids as measured by the carbon labelled octanoic acid breath test: influence of erythromycin and propantheline. Gut 35:333–337, 1994PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • B. D. Maes
    • 1
  • Y. F. Ghoos
    • 1
  • P. J. Rutgeerts
    • 1
  • M. I. Hiele
    • 1
  • B. Geypens
    • 1
  • G. Vantrappen
    • 1
  1. 1.From the Department of Medicine, Division of Gastroenterology and Gastrointestinal Research CentreUniversity Hospital GasthuisbergLeuvenBelgium

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