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Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 1483–1486 | Cite as

A simple urine-test to prove the intake of disulfiram

  • L. M. L. Stolk
  • P. E. Kamp
Short Communications

Abstract

Disulfiram is rapidly metabolised in the human body. Therefore the tests, proposed in the literature, always depend upon the detection of one of the metabolites. This paper describes a simple urine-test, based on the detection of the S-glucuronide of diethyldithiocarbamate. Carbon disulphide is liberated from this glucuronide by acid hydrolysis and is then detected by a colorimetric method. The test is positive until 24 hours after oral intake of a normal dose of disulfiram (200–250 mg, once a day).

Keywords

Disulfiram Diethylamine Reagent Solution Diethyldithiocarbamate Carbon Disulphide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • L. M. L. Stolk
    • 1
  • P. E. Kamp
    • 1
  1. 1.Pharmacy department of the University hospital of AmsterdamAmsterdam

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