Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 1473–1482 | Cite as

Comparative evaluation of excipients for direct compression

IV. The formulation of a high dosage range drug
  • G. K. Bolhuis
  • C. F. Lerk
  • J. R. Moes


A high dosage range drug (acetylsalicylic acid), with different particle size distributions, has been formulated with directly compressible excipients and compressed into tablets. Of the prepared blends, the flow and lubrication properties were investigated. The tablets, containing 500 mg acetylsalicylic acid, were investigated for weight variation, drug content, crushing strength, friability, disintegration time, dissolution rate of the drug and stability after storage for eight weeks at 20‡C and 50% or 85% relative humidity. The results show that knowledge of the properties and interactions of drug, directly compressible excipients and other tablet vehicles makes possible the formulation and compression of different particle size acetylsalicylic acid powders into good quality tablets.


Salicylic Acid Acetylsalicylic Acid Avicel Potato Starch Dissolution Profile 
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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • G. K. Bolhuis
    • 1
  • C. F. Lerk
    • 1
  • J. R. Moes
    • 1
  1. 1.Laboratory for Pharmaceutical TechnologyState UniversityAW GroningenThe Netherlands

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