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Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 1470–1473 | Cite as

Biopharmaceutical studies of fatty suspension suppositories

IV. Influence of particle size on bioavailability of pentobarbital sodium in humans
  • J. J. Rutten-Kingma
  • D. D. Breimer
  • C. J. De Blaey
Article
  • 32 Downloads

Abstract

The bioavailability of pentobarbital sodium was studied in humans, as a function of the size of particles dispersed in fatty suppositories. It was found that particles of 90–100Μm exhibit a faster absorption rate compared with particles smaller than 20Μm. This confirms earlier findings on watersoluble compoundsin vitro as well asin vivo in rats. It seems therefore advisable to consider a lower limit for drug particles in suppositories for readily watersoluble compounds.

Keywords

Pentobarbital Sodium Direct Compression Hexobarbital Partment Linear Model Pharmaceutisch Weekblad Scientific Edition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • J. J. Rutten-Kingma
    • 1
  • D. D. Breimer
    • 1
  • C. J. De Blaey
    • 1
  1. 1.Dept. of Pharmaceutics and Pharmacology, Subfaculty of PharmacyUniversity of Leiden, Gorlaeus LaboratoriaRA LeidenThe Netherlands

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