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Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 1450–1459 | Cite as

An evaluation of the compression characteristics of some magnesium carbonate granulations

  • N. A. Armstrong
  • F. S. S. Morton
Article

Abstract

The relationship between applied pressure and the resulting compact density has been investigated for magnesium carbonate granulated with a number of commonly used granulating agents at a range of concentrations. The resultant data are treated using theHeckel and theCooper andEaton equations. The latter proves unsuitable, but the former gives a rectilinear relationship between pressure and density over a considerable pressure range. The slopes of these lines increase with increasing amount of granulating agent up to a limiting value, beyond which no further increase is obtained. The results are discussed in relation to the plasticity of the granulations.

Keywords

Acetylsalicylic Acid Compression Pressure Wheat Starch Yield Pressure Compact Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • N. A. Armstrong
    • 1
  • F. S. S. Morton
    • 1
  1. 1.Welsh School of PharmacyUWISTCardiffUK

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