Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 1223–1233 | Cite as

Comparative evaluation of excipients for direct compression

III. The formulation of a low and a medium dosage range drug
  • G. K. Bolhuis
  • C. F. Lerk
  • J. R. Moes
  • C. W. A. Mulder
Other Original Articles


Two drugs which are used in a low and a medium dosage range, respectively, have been formulated with directly compressible excipients and compressed into tablets.

Of the prepared blends, the flow and lubrication properties were investigated. The tablets, containing 5 mg prednisone and 50 mg phenobarbitone, respectively, were investigated for content uniformity, crushing strength, friability, disintegration time, dissolution rate of the drug and stability after storage for 8 weeks at 20‡C and 50% or 85% relative humidity.

The results show that with a knowledge of properties and interactions of drugs, directly compressible excipients and other tablet vehicles, formulations can be composed from which tablets with good properties can be prepared.


Avicel Phenobarbitone Dissolution Profile Disintegration Time Aerosil 
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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • G. K. Bolhuis
    • 1
  • C. F. Lerk
    • 1
  • J. R. Moes
    • 1
  • C. W. A. Mulder
    • 1
  1. 1.Laboratory for Pharmaceutical TechnologyState UniversityGroningenThe Netherlands

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