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Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 956–964 | Cite as

Isolation and analytical aspects of Valeriana compounds

  • B. Hazelhoff
  • B. Weert
  • R. Denee
  • Th. M. Malingré
Article

Abstract

Valepotriates are considered as one of the main groups of compounds responsible for the sedative activity of Valeriana preparations. An extraction method for valepotriates is given and the isolation of (iso) valtrate, didrovaltrate andIvhd-valtrate by means of column chromatography on silicagel was shown to be a fast method without giving much decomposition. Toluene-ethyl acetate-methyl ethyl ketone (80+15+5) as a mobile phase gives an excellent indication of the presence of the various valepotriates in Valeriana preparations. For the quantitative determination of valepotriates a direct spectrophotometric scanning onTlc plates was compared with aHplc

Keywords

Anisaldehyde Pharmaceutisch Weekblad Scientific Edition High Pressure Liquid Chro Danthron Valepotriates 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • B. Hazelhoff
    • 1
  • B. Weert
    • 1
  • R. Denee
    • 1
  • Th. M. Malingré
    • 1
  1. 1.Laboratory for PharmacognosyState University GroningenGroningenThe Netherlands

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