Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 950–956 | Cite as

The laxative action of anthracene derivatives

3. Absorption, metabolism and excretion of rhein in the rat
  • L. Lemmens
  • M. Dreessen


After oral administration of rhein to rats, three rhein containing fractions were isolated from the urine: rhein, rheinmonoglucuronide and rheinmonosulphate. Rheinmonoglucuronide was identified by determination of the hydroxyanthraquinone- and the glucuronic acid component and by enzymatic cleavage withΒ-glucuronidase. Rheinmonosulphate could be split by sulphatase. Within 72 h after administering rhein to rats, only 17 to 20% anthracene derivatives could be recovered from the faeces and urine.


Glucuronic Acid Rhein Anthracene Derivative Pharmaceutisch Weekblad Scientific Edition Caecum Content 
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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • L. Lemmens
    • 1
  • M. Dreessen
    • 1
  1. 1.Instituut voor Farmaceutische Wetenschappen, Laboratorium voor FarmacognosieKatholieke Universiteit te LeuvenLeuvenBelgium

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