Biopharmaceutics of rectal administration of drugs in man
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The rectal absorption of paracetamol after administration of fatty suppositories was studied in six human subjects after single doses (500 and 1000 mg) of the drug, using plasma paracetamol concentrations.
Rectal absorption rate was found to be strongly dependent upon the particle size of the drug suspended in the suppository base.
In agreement with studies after rectal administration of aqueous suspensions of paracetamol, rectal absorption rate of paracetamol was dependent upon the volume of the fatty vehicle, rather than on the concentration of the drug under study.
No differences in absorption rate and bioavailability could be detected between Cocoa butter and Witepsol H 15 suppositories with paracetamol.
KeywordsParacetamol Dosage Form Absorption Rate Cocoa Butter Relative Bioavailability
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