Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 212–216 | Cite as

The mechanism of the interaction between digoxin and quinidine

  • P. M. Hooymans
  • F. W. H. M. Merkus
Short Communications


The mechanism of the recently reported interaction between digoxin and quinidine was investigated.

We found a statistically significant decrease in renal clearance of digoxin after adding quinidine to the treatment regime. In 4 patients the digoxin/creatinine renal clearance ratio during quinidine treatment (0.74±0.23, mean ±S.D.) differed significantly (P<0.01) from the ratio after quinidine therapy (1.11±0.20, mean ±S.D.). The ratio was 0.85±0.23 (mean ±S.D.) in 15 patients receiving simultaneous quinidine therapy and 1.22± 0.31 (mean ±S.D.) in 44 patients without quinidine therapy. This difference was significant (P<0.01).

Quinidine did not influencein vitro the distribution of digoxin between plasma and erythrocytes.

The elevation of the serum digoxin level during quinidine therapy can be explained partly by a decrease of the renal digoxin clearance. Our results, however, do not exclude that other mechanisms may also be involved.


Digoxin Quinidine Digoxin Concentration Serum Digoxin Concentration Clearance Ratio 
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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • P. M. Hooymans
    • 1
  • F. W. H. M. Merkus
    • 1
    • 2
  1. 1.R. C. HospitalSittardThe Netherlands
  2. 2.Department of BiopharmaceuticsUniversity of AmsterdamThe Netherlands

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