Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 209–212 | Cite as

Preparation of haematin for injection and its use in the acute attack of porphyrias

  • J. R. B. J. Brouwers
  • J. Ketner
Short Communications


Haematin for injection is of value in the treatment of the acute attacks in hepatic porphyria. The clinical application of haematin and other treatment schemes are discussed.

A new method is presented for the preparation of pure, pyrogen free, haematin for injection from outdated human packed cells.


Digoxin Quinidine Porphyria Serum Digoxin Concentration Haem Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Dean, G. (1978)Practitioner 221, 219–227.PubMedGoogle Scholar
  2. Dhar, G. J., I. Bossenmaier, Z. J. Petryka andC. J. Watson (1978)Acta Med. Scand. 203, 437–443.CrossRefPubMedGoogle Scholar
  3. Doss, M. (1978)Diagnosis and therapy of Porphyrias and Lead Intoxication. Springer-Verlag, Berlin.CrossRefGoogle Scholar
  4. Douer, D., A. Weinberger, J. Pinkas, A. Atsmon andP. Tiqva (1978)J. Am. Med. Assoc. 240, 766–769.CrossRefGoogle Scholar
  5. Fischer, H. (1941)Org. Synt. 21, 53–55.CrossRefGoogle Scholar
  6. Fischer, H., andK. Zeile (1929)Annales 468, 98–116.Google Scholar
  7. Garrod, A.F. (1923)Inborn errors of metabolism, Second Edition. Frowde, Hodder & Stough, London.Google Scholar
  8. Lamon, J. M. (1977)Clin. Chem. 23, 260–263.PubMedGoogle Scholar
  9. Lamon, J. M., B. C. Frykholm, M. Bennett andD. P. Tschudy (1978)Lancet II, 492–493.CrossRefGoogle Scholar
  10. Lancet (1978)I, 1024–1025.Google Scholar
  11. Leonhardt, K. F., R. V. Tiepermann andM. Doss (1978)J. Neurol. 218, 107–123.CrossRefPubMedGoogle Scholar
  12. Meyler, L., andH. M. Peck (1972)Drug Induced Diseases, Volume 4. Excerpta Medica, Amsterdam.Google Scholar
  13. Peterson, A., I. Bossenmaier, R. Cardinal andC. J. Watson (1976)J. Am. Med. Assoc. 235, 520–522.CrossRefGoogle Scholar
  14. Rose, J. A., E. S. Hellman andD. P. Tschudy (1961)Metabolism 10, 514.PubMedGoogle Scholar
  15. Stahl, E. (1969)Thin-layer chromatography. Springer-Verlag, Berlin, p. 604.CrossRefGoogle Scholar
  16. Watson, C. J., J. Dhar, I. Bossenmaier andR. Cardinal (1973)Ann. Intern. Med. 79, 80–83.CrossRefPubMedGoogle Scholar
  17. Watson, C. J., C. A. Pierach, I. Bossenmaier andR. Cardinal (1978)Adv. Intern. Med. 23, 265–286.PubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • J. R. B. J. Brouwers
    • 1
  • J. Ketner
    • 2
  1. 1.Department of Clinical PharmacyRegional Protestant HospitalBennekomThe Netherlands
  2. 2.School of PharmacyUniversity of TennesseeMemphisUSA

Personalised recommendations