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Digestive Diseases and Sciences

, Volume 40, Issue 7, pp 1561–1568 | Cite as

Chronic pancreatitis caused by an autoimmune abnormality

Proposal of the concept of autoimmune pancreatitis
  • Kenji Yoshida
  • Fumitake Toki
  • Tadashi Takeuchi
  • Shin-Ichiro Watanabe
  • Keiko Shiratori
  • Naoaki Hayashi
Pancreatic and Biliary Disorders Case Report

Summary

Several authors have reported a case of chronic pancreatitis associated with Sjögren's syndrome in which an autoimmune mechanism may have been involved in the etrology and in which steroid therapy was effective. We recently encountered a patient with pancreatitis who had hyperglobulinemia, was autoantibody-positive, and responded to steroid therapy. This patient, however, failed to show any evidence of association with Sjögren's syndrome or other collagen diseases. Although the concept of autoimmune hepatitis and the criteria for diagnosing it have been established, autoimmune pancreatitis has not yet been defined as a clinical entity. We report a case of chronic pancreatitis in which an autoimmune mechanism is involved in the etiology and summarize the cases of pancreatitis suspected of being caused by an autoimmune mechanism in the Japanese and English literature.

Key Words

autoimmune pancreatitis autoantibody steroid Sjögren's syndrome primary sclerosing cholangitis 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Kenji Yoshida
    • 1
  • Fumitake Toki
    • 1
  • Tadashi Takeuchi
    • 1
  • Shin-Ichiro Watanabe
    • 1
  • Keiko Shiratori
    • 1
  • Naoaki Hayashi
    • 1
  1. 1.Institute of GastroenterologyTokyo Women's Medical CollegeTokyoJapan

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