Digestive Diseases and Sciences

, Volume 40, Issue 7, pp 1417–1419 | Cite as

Opioid and nonopioid analgesic drug effects on colon contractions in monkeys

  • Alvaro A. B. Ferraz
  • Verne E. Cowles
  • Robert E. Condon
  • William J. Schulte
Motility, Nerve-Gut Interactions, Hormones, and Receptors


Opioid drugs administered postoperatively for pain relief cause increased frequency of nonpropulsive phasic contractions but decreased to absent propulsive migrating contractions in the colon, thus importantly influencing the duration of postoperative ileus. Ketorolac is thought to permit earlier return of bowel function postoperatively compared to morphine. Four monkeys had sets of three strain gauge force transducers implanted on the right and left colon at laparotomy. After recovery, animals were fasted overnight and had colon contractions recorded. After a 1-hr baseline period, 200 μg/kg morphine sulfate or 1 mg/kg ketorolac tromethamine was injected intramuscularly and recording continued. Each animal received four injections of each drug. Records were analyzed visually for frequency of phasic and migrating contractions. There was no difference in the frequency of phasic or migrating contractions after injection of ketorolac. Morphine, as expected, increased the frequency of phasic and decreased the frequency of migrating contractions in the colon. Ketorolac does not affect the frequency of colon contractions.

Key Words

ketorolac morphine analgesics NSAIDs colon contractions gastrointestinal motility smooth muscle contraction 


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  1. 1.
    Frantzides CT, Condon RE, Schulte WJ, Cowles VE: Effects of morphine on colonic myoelectric and motor activity in subhuman primates. Am J Physiol 258:G247-G252, 1990Google Scholar
  2. 2.
    Frantzides CT, Cowles VE, Salaymeh B, Tekin E, Condon RE: Morphine effects on human colonic myoelectric activity in the postoperative period. Am J Surg 163:144–149, 1992Google Scholar
  3. 3.
    Woods JH, Erickson LW, Condon RE, Schulte WJ, Sillin LW: Postoperative ileus. A colonic problem. Surgery 84:527–533, 1978Google Scholar
  4. 4.
    Graber JN, Schulte WJ, Condon RE, Cowles VE: Relationship of duration of postoperative ileus to extent and site of operative dissection. Surgery 92:87–92, 1982Google Scholar
  5. 5.
    Fragen RJ: Ketorolac: Non-opioid analgesic. Curr Surg 50(2):126–131, 1993Google Scholar
  6. 6.
    Pierce RJ, Fragen RJ, Pemberton DM: Intravenous ketorolac tromethamine versus morphine sulfate in the treatment of immediate postoperative pain. Pharmacotherapy 10:111S-111S, 1990Google Scholar
  7. 7.
    Rubin P, Yee JP, Murthy VS, Seavey W: Ketorolac tromethamine (KT) analgesia: No post-operative respiratory depression and less constipation. Clin Pharmacol Ther 41:182, 1987 (abstract)Google Scholar
  8. 8.
    O'Hara DA, Frangen RJ, Kinzer M, Pemberton D: Ketorolac tromethamine as compared with morphine sulfate for treatment of postoperative pain. Clin Pharmacol Ther 41:556–561, 1987Google Scholar
  9. 9.
    Kelley MC, Hocking MP, Marchand SD, Sninsky CA: Ketorolac prevents postoperative small intestinal ileus in rats. Am J Surg 165:107–112, 1993Google Scholar
  10. 10.
    Yee MK, Evans WD, Facey PE, Hayward MWJ, Rosen M: Gastric emptying and small bowel transit in male volunteers after I.M. ketorolac and morphine, Br J Anesth 67:426–431, 1991Google Scholar
  11. 11.
    Power I, Noble DW, Douglas E, Spence AA: Comparison of I.M. ketorolac trometamol and morphine sulphate for pain relief after cholecystectomy. Br J Anesth 65:448–455, 1990Google Scholar
  12. 12.
    Cowles VE, Condon RE, Schulte WJ, Woods JH, Sillin LF: A quarter Wheatstone bridge strain gauge force transducer for recording gut motility. Am J Dig Dis 23:936–939, 1978Google Scholar
  13. 13.
    Sanders KM, Ross G: Effects of endogenous prostaglandin E on intestinal motility. Am J Physiol 234:E204-E208, 1978Google Scholar
  14. 14.
    Coelho JCU, Gouma DJ, Li YF, Moody FG, Schlegel JF: Effect of 16,16-dimethyl prostaglandin E2 on the myoelectric activity of the gastrointestinal tract of the opossum. J Physiol 377:421–427, 1986Google Scholar
  15. 15.
    Horton EW, Main IHM, Thompson CJ, Wright PM, Itoh Z: Effect of orally administered prostaglandin E2 on gastric secretion and gastrointestinal motility in man. Gut 9:655–658, 1968Google Scholar
  16. 16.
    Botting JH, Salzmann R: The effect of indomethacin on the release of prostaglandin E2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation. Br J Pharmacol 50:119–124, 1974Google Scholar
  17. 17.
    Frantzides CT, Lianos EA, Wittmann D, Greenwood B, Edmiston CE: Prostaglandins and modulation of small bowel myoelectric activity. Am J Physiol 262:G488-G497, 1992Google Scholar
  18. 18.
    Konturek SJ, Thor P, Pawlik W, Gustow P, Dembinski A: Role of prostaglandins in the myoelectric, motor, and metabolic activity of the small intestine in the dog.In Motility of the Digestive Tract. M Weinbeck (ed). New York, Raven Press 1982, pp 437–444Google Scholar
  19. 19.
    Thor P, Konturek JW, Konturek SJ, Anderson JW: Role of prostaglandins in control of intestinal motility. Am J Physiol 248:G353-G359, 1985Google Scholar
  20. 20.
    Ekbom G, Schulte WJ, Condon R, Woods JH, Cowles V: Effects of narcotic analgesics on bowel motility in subhuman primates. J Surg Res 28:293–296, 1980Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Alvaro A. B. Ferraz
    • 1
    • 2
    • 3
  • Verne E. Cowles
    • 1
    • 2
    • 3
  • Robert E. Condon
    • 1
    • 2
    • 3
  • William J. Schulte
    • 1
    • 2
    • 3
  1. 1.Department of Surgery (Rm 3510)The Medical College of WisconsinMilwaukee
  2. 2.Digestive Diseases Research CenterMedical College of WisconsinMilwaukee
  3. 3.Surgical and Research ServicesZablocki VA Medical CenterMilwaukee

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