Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients
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Summary
Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients. Nine asthmatic men received an IV infusion of 240 mg theophylline at a constant rate for 30 min.
The theophylline concentrations in erythrocytes and blister fluid were 37 % and 78 % of those in plasma. There was not a strong correlation between erythrocyte or blister fluid penetration and the clinical effect of theophylline.
Key words
Theophylline, Asthma blister fluid, erythrocytes, free levels, peak expiratory flow, pharmacokineticsPreview
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