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European Journal of Clinical Pharmacology

, Volume 43, Issue 6, pp 663–665 | Cite as

The pharmacokinetics of theβ2-adrenoceptor agonist fenoterol in healthy women

  • K. Warnke
  • R. Hildebrandt
  • K. Günther
  • U. Langen
  • U. Gundert-Remy
Short Communications

Summary

We have studied the pharmacokinetics of fenoterol in healthy women during and after a 3 h intravenous infusion of different doses within the therapeutic range for tocolysis (0.5 μg·min−1, 1.0 μg·min−1, and 2.0 μg·min−1). A specific and sensitive radioimmuno-assay was used for the determination of fenoterol. For compartmental analysis the plasma concentration time data were fitted with the TOPFIT program, assuming two exponentials.

The total clearance of fenoterol increased with dose (1299 ml·min−1 at 0.5 μg·min−1, 1483 ml·min−1 at 1.0 μg·min−1, and 1924 ml·min−1 at 2.0 μg·min−1), as did the apparent volume of distribution (from 491 at the lowest to 851 at the highest dose).

In contrast, the apparent half-lives were not dose-dependent, with t1/2·λ1 4.8 min and t1/2·λ2 52 min.

Key words

Fenoterol pharmacokinetics, non-linearity 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • K. Warnke
    • 1
  • R. Hildebrandt
    • 2
  • K. Günther
    • 1
  • U. Langen
    • 1
  • U. Gundert-Remy
    • 1
  1. 1.Abteilung für Experimentelle und Klinische PharmakologieInstitut für Arzneimittel BundesgesundheitsamtBerlin 65Germany
  2. 2.Frauenklinik und -poliklinik der Freien Universität BerlinGermany

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