, Volume 11, Issue 5, pp 282–286 | Cite as

Application of the headspace analysis to systems with unknown partition coefficients

  • B. V. Ioffe
  • A. G. Vitenberg


Possibilities for the quantitative determination of volatile constituents in solutions by headspace analysis are investigated in cases where the partition coefficients (K) depend on the composition of the object under study. The timeconsuming work of revealing and taking into account the effect of the analytes and the other present constituents on the magnitude of K can be eliminated if simultaneously with determining the analyte content in the equilibrium gas one also measures the partition coefficients characteristic for the solution under study. These quantities can be obtained by repeated analysis of the equilibrium gas after partial removal of the volatile solution constituents. At small K (0.1 to 10) the required change of analyte concentration in the solution can be attained by single replacement of the equilibrium gas by pure gas, and at large K, by passing a known volume of pure gas through the solution under study under equilibrium conditions. The paper establishes the range of applicability of each version, provides the necessary equations and presents the results of an experimental check in the case of determining alcohol admixtures in water solutions.


Alcohol Organic Chemistry Equilibrium Condition Partition Coefficient Quantitative Determination 
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Copyright information

© Friedr. Vieweg & Sohn Verlagschesellschaft mbH 1978

Authors and Affiliations

  • B. V. Ioffe
    • 1
  • A. G. Vitenberg
    • 1
  1. 1.Chemistry DepartmentLeningrad State UniversityLeningradU.S.S.R.

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