European Journal of Pediatrics

, Volume 155, Issue 11, pp 959–962 | Cite as

Hyponatremia in patients with nocturnal enuresis treated with DDAVP

  • W. L. M. Robson
  • J. P. Nørgaard
  • A. K. C. Leung


Treatment of nocturnal enuresis with DDAVP is associated with a low incidence of adverse effects. The only reported serious adverse effect is seizure or altered level of consciousness due to water intoxication. We reviewed 14 articles that reported data on serum sodium in patients treated with DDAVP for nocturnal enuresis and 11 articles that reported patients who developed a seizure or altered level of consciousness during treatment with DDAVP for nocturnal enuresis. Excess fluid intake was identified as a contributing factor in 6 of the 11 case reports.

Key words

Nocturnal enuresis DDAVP Hyponatremia Water intoxication 



arginine vasopressin


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • W. L. M. Robson
    • 1
  • J. P. Nørgaard
    • 2
  • A. K. C. Leung
    • 3
  1. 1.Department of Pediatric Nephrology The Children's HospitalGreenville Hospital SystemGreenvilleUSA
  2. 2.Division of Pediatric UrologyRigshospitaletCopenhagenDenmark
  3. 3.Department of PediatricsUniversity of Calgary and the Alberta Children's HospitalCalgaryCanada

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