European Journal of Pediatrics

, Volume 155, Issue 10, pp 880–884

Molecular analysis of medulloblastomas occurring simultaneously in monozygotic twins

  • W. Scheurlen
  • N. Sörensen
  • W. Roggendorf
  • J. Kühl
Hematology/Oncology

Abstract

We report male monocygotic twins with concordant desmoplastic medulloblastoma diagnosed at the age of 20 months. Both tumours were completely removed. As chromosomal loci 17p13 and 9831 are frequently altered in medulloblastoma these regions were analysed in both tumours in detail using restriction fragment length polymorphism and microsatellite analysis. No common aberration was found. The c-myc gene on chromosome 8g21 was not amplified.

Key words

Medulloblastoma Monozygotic twins Loss of heterozygosity Chromosome l7p 13 and 9g31 

Abbreviations

APC

adenomatous polyposis coli

LOH

loss of heterozygosity

NBCCS

nevoid basal cell carcinoma syndrome

PBL

peripheral blood lymphocyte

PCR

polymerase chain reaction

PNET

primitive neuro-ectodermal tumour

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • W. Scheurlen
    • 1
  • N. Sörensen
    • 2
  • W. Roggendorf
    • 3
  • J. Kühl
    • 1
  1. 1.Department of PaediatricsUniversity of WürzburgWurzburgGermany
  2. 2.Department of Paediatric NeurosurgeryUniversity of WürzburgWurzburgGermany
  3. 3.Department of NeuropathologyUniversity of WürzburgWürzburgGermany

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