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Digestive Diseases and Sciences

, Volume 41, Issue 3, pp 614–620 | Cite as

Increased substance P receptor expression by blood vessels and lymphoid aggregates inClostridium difficile-induced pseudomembranous colitis

  • Christopher R. Mantyh
  • John E. Maggio
  • Patrick W. Mantyh
  • Steven R. Vigna
  • Theodore N. Pappas
Case Report

Key words

inflammation inflammatory bowel disease pseudomembranous colitis receptors substance P toxin A 

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References

  1. 1.
    Bartlett JG, Chang TW, Gurwith M, Garbach SL, Onderdonk AB: Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 298:531–534, 1978Google Scholar
  2. 2.
    Price AB, Davies DR: Pseudomembranous colitis. J Clin Pathol 30:1–12, 1977Google Scholar
  3. 3.
    Bartlett JG: Antibiotic-associated colitis. Dis Month 30:1–54, 1984Google Scholar
  4. 4.
    Lyerly DM, Krivan HC, Wilkins TD:Clostridium difficile: Its disease and toxins. Clin Microbiol Rev 1:1–18, 1988Google Scholar
  5. 5.
    Kelly CP, Pothoulakis C, LaMont JT:Clostridium difficile colitis. N Engl J Med 330:257–262, 1994Google Scholar
  6. 6.
    Pothoulais C, LaMont JT, Eglow R, Gao N, Rubins JB, Theoharides TC, Dickey BF: Characterization of rabbit ileal receptors forClostridium difficile toxin A. Evidence for a receptor-coupled G protein. J Clin Invest 88:119–125, 1991Google Scholar
  7. 7.
    Kelly CP, Becker S, Linevsky JK, Joshi MA, O'Keane JC, Dickey BF, LaMont JT, Pothoulakis C: Neutrophil recruitment inClostridium difficile toxin A enteritis in the rabbit. J Clin Invest 93:1257–1265, 1994Google Scholar
  8. 8.
    Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O'Keane JC, Snider RM, Leeman SE: CP-96,345, a substance P antagonist, inhibits rat intestinal responses toClostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci USA 91:947–951, 1994Google Scholar
  9. 9.
    Barnes PJ: Sensory nerves, neuropeptides, and asthma. Ann NY Acad Sci 629:359–370, 1991Google Scholar
  10. 10.
    Levine JD, Clark R, Devor M, Helms C, Moskowitz MA, Basbaum AI: Intraneuronal substance P contributes to the severity of experimental arthritis. Science 226:547–549, 1984Google Scholar
  11. 11.
    Mantyh CR, Gates TS, Zimmerman RP, Welton ML, Passaro EP Jr, Vigna SR, Maggio JE, Kruger L, Mantyh PW: Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc Natl Acad Sci USA 85:3235–3239, 1988Google Scholar
  12. 12.
    Mantyh PW, Catton MD, Boehmer CG, Welton ML, Passaro EP Jr, Maggio JE, Vigna SR: Receptors for sensory neuropeptides in human inflammatory diseases: Implications for the effector role of sensory neurons. Peptides 10:627–645, 1989Google Scholar
  13. 13.
    Mantyh CR, Vigna SR, Bollinger RR, Mantyh PW, Maggio JE, Pappas TN: Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology 109:850–860, 1995Google Scholar
  14. 14.
    Triadafilopoulos G, Pothoulakis C, O'Brien MJ, LaMont JT: Differential effects ofClostridium difficile toxins A and B on rabbit ileum. Gastroenterology 93:273–279, 1987Google Scholar
  15. 15.
    Mitchell TJ, Ketley JM, Haslam SC, Stephen J, Burdon DW, Candy DCA, Daniel R: Effect of toxin A and B ofClostridium difficile on rabbit ileum and colon. Gut 27:78–85, 1986Google Scholar
  16. 16.
    Castagliuolo I, LaMont JT, Letourneau R, Kelly C, O'Keane JC, Jaffer A, Theoharides TC, Pothoulakis C: Neuronal involvement in the intestinal effects ofClostridium difficile toxin A andVibrio cholerae enterotoxin in rat ileum. Gastroenterology 107:657–665, 1994Google Scholar
  17. 17.
    Lotz M, Vaughan JH, Carson DA: Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241:1218–1221, 1988Google Scholar
  18. 18.
    Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D: Mast-cell heterogeneity: Effects of neuroenteric peptides on histamine release. J Immunol 135:1331–1337, 1985Google Scholar
  19. 19.
    Wozniak A, McLennan G, Betts WH, Murphy GA, Scicchitano R: Activation of human neutrophils by substance P: Effect on FMLP-stimulated oxidative and arachidonic acid metabolism and on antibody-dependent cell-mediated cytotoxicity. Immunology 68:359–364, 1989Google Scholar
  20. 20.
    Lembeck F, Holzer P: Substance P as a neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg's Arch Pharmacol 310:175–183, 1979Google Scholar
  21. 21.
    Nakagawa N, Iwamoto I, Yoshida S: Effect of substance P on the expression of an adhesion molecule ICAM-1 in human vascular endothelial cells. Regul Pept 46:223–224, 1993Google Scholar
  22. 22.
    Greeno EW, Mantyh P, Vercellotti GM, Moldow CF: Functional neurokinin 1 receptors for substance P are expressed by human vascular endothelium. J Exp Med 177:1269–1276, 1993Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Christopher R. Mantyh
    • 1
    • 2
    • 3
  • John E. Maggio
    • 1
    • 2
    • 3
  • Patrick W. Mantyh
    • 1
    • 2
    • 3
  • Steven R. Vigna
    • 1
    • 2
    • 3
  • Theodore N. Pappas
    • 1
    • 2
    • 3
  1. 1.From the Departments of Surgery, Cell Biology and MedicineDuke University Medical CenterDurham
  2. 2.Molecular Neurobiology LaboratoryUniversity of MinnesotaMinneapolis
  3. 3.Department of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBoston

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