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Pharmaceutisch Weekblad

, Volume 8, Issue 6, pp 300–301 | Cite as

Free radical formation and oxidative damage in rat tissue

  • Rinette H. M. Julicher
  • Lydi Sterrenberg
  • J. Noordhoek
  • A. Bast
  • J. F. Koster
Abstracts of Dutch Ph.D. Theses
  • 20 Downloads

Key words

Anoxia Biotransformation Calcium paradox Doxorubicin Free radicals Ischemia Vitamin E 

Results are also published in the following papers

  1. Julicher RHM, Sterrenberg L, Koomen JM, Bast A, Noordhoek J. Evidence for lipid peroxidation during the calcium-paradox in vitamin E-deficient rat heart. Naunyn Schmiedebergs Arch Pharmacol 1984;326:87–9.CrossRefPubMedGoogle Scholar
  2. Julicher RHM, Tijburg LBM, Sterrenberg L, Bast A, Koomen JM, Noordhoek J. Decreased defence against free radicals in rat heart during normal reperfusion after hypoxic, ischaemic and calcium-free perfusion. Life Sci 1984;35:1281–8.CrossRefPubMedGoogle Scholar
  3. Sterrenberg L, Julicher RHM, Bast A, Noordhoek J. Adriamycin stimulates NADPH-dependent lipid peroxidation in liver microsomes not only by enhancing the production of O2· and H2O2, but also by potentiating the catalytic activity of ferrous ions. Toxicol Lett 1984;22:153–9.CrossRefPubMedGoogle Scholar
  4. Julicher RHM, Sterrenberg L, Haenen GRMM, Bast A, Noordhoek J. Sex differences in the cellular defence system against free radicals from oxygen or drug metabolites in rat. Arch Toxicol 1984;56:83–6.CrossRefPubMedGoogle Scholar
  5. Julicher RHM, Van der Laarse A, Sterrenberg L, Bloys van Treslong CHF, Bast A, Noordhoek J. The involvement of an oxidative mechanism in the adriamycin-induced toxicity in neonatal rat heart cell cultures. Res Commun Chem Pathol Pharmacol 1985;47:35–47.PubMedGoogle Scholar
  6. Sterrenberg L, Julicher RHM, Bast A, Noordhoek J. Effect of vitamin E on the balance between pro- and antioxidant activity of ascorbic acid in microsomes from rat heart, kidney and liver. Toxicol Lett 1985;25:153–9.CrossRefPubMedGoogle Scholar
  7. Sterrenberg L, Julicher RHM, Goossens PAL, Bast A, Noordhoek J. Anthracycline-induced oxygen consumption and oxidative damage in rat liver microsomes are not necessarily coupled. A study with 8 structurally related anthracyclines. Free Radical Res Commun 1985;I:41–54.Google Scholar
  8. Van der Laarse A, Julicher RHM, Sterrenberg L, Bloys van Treslong CHF. Lipid peroxidation in neonatal rat heart cell cultures: effect of cumene hydroperoxide. Cardiovascular Res 1986;20:20–5.Google Scholar
  9. Julicher RHM, Sterrenberg L, Walenbergh LHP, Bast A, Noordhoek J. The effect of vitamin E-deficiency in isolated rat heart on the cellular defence system against free radicals during normal reperfusion after hypoxic, ischaemic and calcium-free perfusion. Free Radical Res Commun 1986;I:225–33.Google Scholar
  10. Julicher RHM, Sterrenberg L, Bast A, Riksen ROWMM, Koomen JM, Noordhoek J. The role of lipid peroxidation in the acute adriamycin-induced cardiotoxicity as studied in isolated rat heart. J Pharm Pharmacol 1986;38:277–82.PubMedGoogle Scholar
  11. Sterrenberg L, Julicher RHM, Goossens PAL, Bast A, Noordhoek J. Non-enzymic lipid peroxidation in microsomes and microsomal phospholipids induced by anthracyclines. Free Radical Res Commun 1986;I:369–78.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • Rinette H. M. Julicher
    • 3
  • Lydi Sterrenberg
    • 3
  • J. Noordhoek
    • 3
  • A. Bast
    • 1
  • J. F. Koster
    • 2
  1. 1.Amsterdam
  2. 2.Rotterdam
  3. 3.Department of Biomedical Pharmacy, Subfaculty of PharmacyState University of UtrechtUtrechtThe Netherlands

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