Influence of salicylate and anaesthesia on the rectal absorption of theophylline in rats
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The effect of sodium salicylate and anaesthesia on the rectal absorption of theophylline was evaluated in rats. Theophylline proved to be slowly but completely absorbed on rectal infusion in conscious rats, compared with intravenous infusion. Pentobarbital anaesthesia did not influence absorption. In contrast to literature data, the results with salicylate showed that rectal absorption of theophylline was not enhanced.
Key wordsAbsorption Administration, rectal Anesthesia Drug therapy, combination Pentobarbital Salicylates Theophylline
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- 2.Morimoto K, Hama I, Nakamoto Y, Takeeda T, Hirano E, Morisaka K. Pharmaceutical studies of polyacrylic acid aqueous gel bases: absorption of insulin from polyacrylic acid aqueous gel bases following rectal administration in alloxan diabetic rats and rabbits. J Pharm Dyn 1980;3:24–32.Google Scholar
- 6.Muranushi N, Kinugawa M, Nakijima Y, Muranishi S, Sezaki H. Mechanism for the inducement of the intestinal absorption of poorly absorbed drugs by mixed micelles. I. Effect of various lipid-bile salts mixed micelles on the intestinal absorption of streptomycin in rat. Int J Pharm 1980;4:271–9.CrossRefGoogle Scholar