Glucose metabolism in the caudate nuclei of patients with eating disorders, measured by PET
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Regional cerebral glucose metabolism was measured with18F-2-fluoro-2-deoxyglucose and positron emission tomography in nine patients with bulimia nervosa and in seven patients with anorexia nervosa. Relative caudate glucose metabolism (caudate glucose metabolism divided by global cerebral glucose metabolism) was significantly higher in anorexia nervosa than in bulimia nervosa, suggesting that caudate hyperactivity is characteristic of the anorexic state. Whether increased caudate function is a consequence of anorexic behaviour or whether it is directly involved in the pathogenesis of anorexia nervosa is an issue still to be clarified.
Key wordsBulimia nervosa Anorexia nervosa Caudate nuclei Glucose metabolism Positron emission tomography
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- American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. American Psychiatric Association, Washington, D.C.Google Scholar
- Broocks A, Liu J, Pirke KM (1989) Influence of hyperactivity on the metabolism of central monoaminergic neurotransmitters and reproductive function in the semistarved rat. In: Pirke KM, Wuttke W, Schweiger U (eds) The menstrual cycle and its disorders. Springer, Berlin Heidelberg New York, pp 88–96Google Scholar
- Delvenne V, Lotstra F, Goldman S, Mendelbaum K, Appelbaum-Fondu J, Bidaut LM, Luxen A, Schoutens A, Mendlewicz J (1990) Caudate nuclei hypermetabolism in eating disorders detected by the 18F-fluorodeoxyglucose method and positron emission tomography (1990). 17th Congress of Collegium Internationale Neuro-Psychopharmacologicum, Kyoto, Japan, abstracts vol II, p 330Google Scholar
- Herholz K, Krieg JC, Emrich HM, Beil C, Pirke KM, Heiss WD (1986) Regional cerebral glucose metabolism (PET) in anorexia nervosa. In: Shagass C, Josiassen R, Bridger WH, Weiss KJ, Stoff D, Simpson GM (eds) Biological psychiatry 1985, vol 7. Elsevier, New York, pp. 386–391Google Scholar
- Teuber HL (1976) Complex functions of the basal ganglia. In: Yahr MD (ed) The basal ganglia. Raven Press, New York, pp 151–168Google Scholar