Calcified Tissue Research

, Volume 4, Issue 1, pp 94–100 | Cite as

The effect of excessive acid feeding on bone

  • Uriel S. Barzel
Original Papers


Excessive administration of ammonium chloride to normal adult male rats receiving a diet adequate in vitamin D caused the development of osteoporosis. The osteoporosis was due to loss of bone substance and bone mineral associated with increased bone resorption.

Key words

Acid Base equilibrium Acidosis Bone Resorption Metabolism Osteoporosis 


L'administration chronique de chlorure d ammonium à des rats adultes normaux, soumis à un régime contenant un taux approprié de vitamine D, provoque une ostéoporose. Celle-ci est provoquée par une perte de substance d'os et de minéral osseux, associée à l'augmentation de la résorption osseuse.


Chronische Verabreichung von Ammoniumchlorid an normale ausgewachsene männliche Ratten, die eine entsprechende Vitamin-D-haltige Diät erhalten, verursacht die Entwicklung einer Osteoporose.

Die Osteoporose entsteht auf Grund eines Verlustes von Knochensubstanz und Knochenmineral, in Begleitung einer erhöhten Knochenresorption.


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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • Uriel S. Barzel
    • 1
  1. 1.Metabolic Endocrine LaboratoryDivision of Medicine Montefiore Hospital and Medical Center BronxBronx

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