Lymphocyte subsets and interleukin-2 receptors in autistic children
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Blood samples were obtained from 10 male autistic children ages 7–15 years and 10 age-matched, male, healthy controls. Lymphocyte subsets (helper-inducer, suppressor-cytotoxic, total T, and total B cells) were enumerated using monoclonal antibodies and flow cytometry. Bound and soluble interleukin-2 receptors were assayed in unstimulated blood samples and in cell cultures following 72-hour stimulation with phytohemagglutinin. The children with autism had a lower percentage of helper-inducer cells and a lower helpersuppressor ratio, with both measures inversely related to the severity of autistic symptoms (r=−.56 and −.68, respectively). A lower percentage of lymphocytes expressing bound interleukin-2 receptors following mitogenic stimulation was also noted, and this too was inversely related to the seventy of autistic symptoms.
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- Smith, K. A. (1988). Interleukin-2: Inception, impact, and implications.Science, 240, 1126–1146.Google Scholar
- Wright, H. H., Abramson, R. K., Self, S., Genco, P., & Cuccaro, M. L. (1990).Serotonin may affect lymphocyte cell surface markers in autistic probands. Presented at the Annual Meeting of the American Academy of Child and Adolescent Psychiatry, San Francisco, CA. (NR abstract 12).Google Scholar
- Zimmerman, A. W., Frye, V. H., & Potter, N. T. (1993). Immunological aspects of autism.International Pediatrics, 8, 199–204.Google Scholar