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Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1698–1703 | Cite as

Zinc and cerium sulfadiazine, zinc sulfathiazole. Real compounds or physical mixtures?

  • A. Bult
  • N. Hulsing
  • J. W. Weyland
Original Articles
  • 31 Downloads

Abstract

Zinc and cerium sulfadiazine (SD) are recommended for use in topical burn therapy. In the literature the compositions Zn(SD)2 and Ce(SD)3 were suggested for these metal compounds prepared in aqueous solution. Actually a physical mixture of the metal hydroxide and free sulfadiazine (HSD) is formed. The presence of HSD in the mixture makes these products less suitable in local therapy. Preparation in ethanol results in a Zn-SD compound of indeterminate composition. The antibacterial zinc compound of sulfathiazole (HST) prepared in aqueous solution has the composition Zn(ST)2.

Keywords

Public Health Zinc Aqueous Solution Internal Medicine Hydroxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Avery, G. S. (1976)Drug Treatment. Adis Press, Sydney, 350.Google Scholar
  2. Baenziger, N. C., andA. W. Struss (1976)Inorg. Chem. 15, 1807.Google Scholar
  3. Bleumink, E., andA. H. Klokke (1971)Lancet I, 1425.Google Scholar
  4. Bult, A., andH. B. Klasen (1978)J. Pharm. Sci. 67, 284;Ibidem (1980)Arch. Pharm., in press.Google Scholar
  5. Bult, A., J. D. Uitterdijk andH. B. Klasen (1979)Transition Met. Chem. 4, 285.Google Scholar
  6. Coenegracht, P. M. J., J. P. Franke andH. J. Metting (1973)Anal. Chim. Acta 65, 375.Google Scholar
  7. Cook, D. S., andM. F. Turner (1975)Chem. Soc. Perkin II, 1021.Google Scholar
  8. Cotton, F. A., andG. Wilkinson (1972)Advanced Inorganic Chemistry, 3rd edition. Interscience Publishers, New York, 513.Google Scholar
  9. Fox, Ch. L. (1968)Arch. Surg. 96, 184;Ibidem (1977)Pahlavi Med. J. 8, 45.Google Scholar
  10. Fox, Ch. L., S. M. Modak andJ. W. Stanford (1976)Surg. Gynecol Obstet. 42, 553;Ibidem (1978)Burns 4, 233;Ibidem (1979)Scand. J. Plast. Reconstr. Surg. 13, 89.Google Scholar
  11. Fox, Ch. L., W. W. Monafo, V. H. Ayvazian, A. M. Skinner, S. M. Modak, J. W. Stanford andC. Condict (1977)Surg. Gynecol. Obstet. 144, 668.Google Scholar
  12. Holzbecher, Z., L. Divis, M. Král, L. Sůcha andF. Vlácil (1976)Handbook of Organic Reagents in Inorganic Analysis. Ellis Horwood Ltd., Chichester, 449.Google Scholar
  13. Informatorium Medicamentorum (1978)Knmp, 's-Gravenhage, 265.Google Scholar
  14. Meyler, L., andA. Herxheimer (1968)Side Effects of Drugs, Vol. VI. Excerpta Medica Foundation, Amsterdam, 254.Google Scholar
  15. Narang, K. K., andJ. K. Gupta (1976)J. Inorg. Nucl Chem. 38, 589;Ibidem (1977)Transition Met. Chem. 2, 181.Google Scholar
  16. Sawicki, C. R., andF. P. Scaringelli (1971)Microchem. J. 16, 657.Google Scholar
  17. Turczan, J., andT. Medwick (1972)J. Pharm. Sci. 61, 434.Google Scholar
  18. Welcher, F. J. (1958)The analytical uses of ethylenediamine tetraacetic acid. D. van Nostrand Company Inc., New York, 149.Google Scholar
  19. Yamashita, S., Y. Seyama andN. Ishkawa (1978)Experientia 34, 472.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • A. Bult
    • 1
  • N. Hulsing
    • 1
  • J. W. Weyland
    • 1
  1. 1.Laboratory for Pharmaceutical and Analytical ChemistryState UniversityAw GroningenThe Netherlands

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