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Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1669–1679 | Cite as

Recent advances in the classification of α- adrenoceptors

  • P. A. Van Zwieten
  • P. B. M. W. M. Timmermans
Review Articles

Abstract

In contrast to the recent emphasis onβ-adrenoceptors, the adrenergic receptors of the α-type have been some-what neglected. However, the concept of pre- and post-synaptic α-adrenoceptors, which has been extended by the subdivision into α1- and α2-subtypes, has caused a revival of interest in this class of adrenoceptors. A clear distinction can now be made between pre- and post-synaptic α-adrenoceptors. This classification is based upon the anatomical localisation of the α-receptors in question. More recently, a subdivision into α1- and α2 subtypes has been generally recognised. This subdivision is based upon the drug specificities of these two distinct types of α-receptors. The present survey is dealing with the classification of α-adrenoceptors and their various subtypes. At present, a number of very selective agonists and antagonists of the subtypes of α-adrenoceptors mentioned above have become available. Their properties and possible therapeutic relevance are discussed in the present survey.

Keywords

Public Health Internal Medicine Anatomical Localisation Distinct Type Clear Distinction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • P. A. Van Zwieten
    • 1
  • P. B. M. W. M. Timmermans
    • 1
  1. 1.Division of Pharmacotherapy, Department of PharmacyUniversity of AmsterdamTV AmsterdamThe Netherlands

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