Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1417–1420 | Cite as

Diffusion of drugs through multibarrier

  • M. Friedman
  • M. Donbrow
Short Communications


Diffusional mass transfer across a serial 2 or 3 unit laminate barrier of ethyl cellulose and polyethylene glycol membranes was studied using caffeine and salicylic acid as model drugs. The overall membrane diffusional resistance was found to be the sum of the intrinsic membrane resistances. When the resistance of one layer was much higher than that of the others, the permeability was then controlled by the single layer in the laminate.


Public Health Cellulose Ethyl Internal Medicine Mass Transfer 
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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • M. Friedman
    • 1
  • M. Donbrow
    • 1
  1. 1.Department of Pharmacy, School of PharmacyHebrew University - Hadassah Medical SchoolJerusalemIsrael

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