Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1329–1337 | Cite as

Groei van micro-organismen in infusievloeistoffen

  • C. Baggerman
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Samenvatting

In dit artikel wordt een overzicht gegeven van de literatuur betreffende microbiele groei in infusievloeistoffen. Hieruit blijkt dat vooral verschillende soorten van de familie der enterobacteriaceae zich kunnen vermeerderen in deze oplossingen in tegenstelling tot stafylokokken die deze eigenschap niet bezitten.Candida albicans blijkt alleen in aminozuur- en Total Parenteral Nutrition-oplos-singen te groeien.

Van de diverse oplossingen bezitten vooral glucoseoplossing 5% en vetemulsies groeibevorderende eigenschappen. Ook wordt ingegaan op mogelijke oorzaken van contaminatie bij het gebruik in de praktijk. Tenslotte wordt de betekenis van de microbiele groei voor het bereiingsproces alsmede voor het ontstaan van pyrogenen besproken.

Abstract

In this article a review is given of current knowledge regarding microbial growth in infusion fluids. From this it appears that especially some species of the enterobacteriaceae are able to proliferate well in these solutions, whileStaphylococcus species do not possess this property.Candida albicans demonstrates growth only in amino acid- and Total Parenteral Nutrition-solutions.

Of the various solutions especially glucose 5% and fat emulsions show growth-promoting properties. The possible cause of contamination while using these solutions is discussed. Finally the meaning of these data with regard to the production process and to the origin of pyrogens is discussed.

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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • C. Baggerman
    • 1
  1. 1.Centraal Laboratorium van de BloedtransfusiedienstAmsterdam

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