Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1131–1132 | Cite as

On the stability-indicating properties of some spectrometric assays for corticosteroids

  • H. Bundgaard
  • J. Hansen
Short Communication


RecentlyDekker (1980) has questioned the stability-indicating properties of some spectrometric methods for corticosteroids due to the finding of 17-deoxyprednisolone as one of the decomposition products of prednisolone under anaerobic conditions. On the basis of results of recent stability studies on hydrocortisone the conclusion is drawn that significant interference of 17-deoxy steroids in the spectrometric assays may only occur in rare cases and under special degradation conditions.


Public Health Steroid Internal Medicine Corticosteroid Hydrocortisone 
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  2. Bundgaard, H., andJ. Hansen (1979)Arch. Pharm. Chemi, Sci. Ed. 7, 19.Google Scholar
  3. Dekker, D. (1979)Pharm. Weekblad Sci. Ed. 1, 112;Ibidem (1980)2, 28.Google Scholar
  4. Görög, S., andG. Szász (1978)Analysis of Steroid Hormone Drugs. Elsevier Scientific Publishing Company, Amsterdam-Oxford-New York.Google Scholar
  5. Hansen, J., andH. Bundgaard (1979)Arch. Pharm. Chemi, Sci. Ed. 7, 135;Ibidem (1980)8, 91.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • H. Bundgaard
    • 1
  • J. Hansen
    • 1
  1. 1.Department of PharmaceuticsThe Royal Danish School of PharmacyCopenhagenDenmark

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