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Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 1131–1132 | Cite as

On the stability-indicating properties of some spectrometric assays for corticosteroids

  • H. Bundgaard
  • J. Hansen
Short Communication
  • 15 Downloads

Abstract

RecentlyDekker (1980) has questioned the stability-indicating properties of some spectrometric methods for corticosteroids due to the finding of 17-deoxyprednisolone as one of the decomposition products of prednisolone under anaerobic conditions. On the basis of results of recent stability studies on hydrocortisone the conclusion is drawn that significant interference of 17-deoxy steroids in the spectrometric assays may only occur in rare cases and under special degradation conditions.

Keywords

Public Health Steroid Internal Medicine Corticosteroid Hydrocortisone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bundgaard, H. (1978)Arch. Pharm. Chemi, Sci. Ed. 6, 127.Google Scholar
  2. Bundgaard, H., andJ. Hansen (1979)Arch. Pharm. Chemi, Sci. Ed. 7, 19.Google Scholar
  3. Dekker, D. (1979)Pharm. Weekblad Sci. Ed. 1, 112;Ibidem (1980)2, 28.Google Scholar
  4. Görög, S., andG. Szász (1978)Analysis of Steroid Hormone Drugs. Elsevier Scientific Publishing Company, Amsterdam-Oxford-New York.Google Scholar
  5. Hansen, J., andH. Bundgaard (1979)Arch. Pharm. Chemi, Sci. Ed. 7, 135;Ibidem (1980)8, 91.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • H. Bundgaard
    • 1
  • J. Hansen
    • 1
  1. 1.Department of PharmaceuticsThe Royal Danish School of PharmacyCopenhagenDenmark

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