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Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 266–270 | Cite as

Stability of corticosteroids under anaerobic conditions

II. 17-deoxy-21-dehydroprednisolone
  • D. Dekker
Original Articles

Abstract

One of the identified decomposition products formed during the anaerobic decomposition of prednisolone, is 17-deoxy-21-dehydroprednisolone. This product can only be detected when the decomposition of prednisolone takes place at about pH = 6 or lower pH values.

The Chromatographic properties, the isolation and the structure elucidation of 17-deoxy-21-dehydroprednisolone are given.

Keywords

Public Health Internal Medicine Corticosteroid Prednisolone Anaerobic Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Conbere, J. P., andN. J. Fanwood (1956) USPatent 2, 773, 077.Google Scholar
  2. Dekker, D. (1979)Pharm. Weekblad Sci. Ed. 1, 112.Google Scholar
  3. Lewbart, M. L., andV. R. Mattox (1964)J. Org. Chem. 29, 513.Google Scholar
  4. Porter, C. C., andR. H. Silber (1950)J. Biol. Chem. 185, 210.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • D. Dekker
    • 1
  1. 1.Department of Analytical Pharmacy, Faculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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