Advertisement

Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 262–265 | Cite as

Determination of free acid and anhydride content in aliphatic and aromatic cyclic anhydrides by conductometric titration

  • S. J. Sie-Tjoeng
  • H. J. De Jong
Original Articles
  • 95 Downloads

Abstract

The simultaneous determination of free acid and anhydride content in samples of cyclic aliphatic and aromatic anhydrides was studied. Conductometric titration with methanolic sodium methoxide while using acetone as a solvent proves to be a reliable method, applicable to small amounts of sample (0.3 mmol). The results of the conductometric method were checked by potentiometric titration of free acid with trinonylamine, and by determination of the total acid content after complete hydrolysis of the sample.

Keywords

Sodium Acetone Anhydride Acid Content Reliable Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berger, W. E. (1940)Helv. Chim. Acta 23, 43.Google Scholar
  2. Bourne, E. J., M. Stacey, J. C. Tatlow andR. Worrall (1958)J. Chem. Soc. 3268.Google Scholar
  3. Hammond, C. W. (1965) In:Organic Analysis, Vol. III. Interscience, New York.Google Scholar
  4. Iyer, V., andN. K. Mathur (1965)Anal. Chim. Acta 33, 554.Google Scholar
  5. Iyer, V., andN. K. Mathur (1966)Talanta 13, 1592.Google Scholar
  6. Jones, I., andF. G. Soper (1963)J. Chem. Soc. 135.Google Scholar
  7. Kortüm, G., Vogel andK. Andrussow (1961)Dissociation constants of organic acids. Butterworths, London.Google Scholar
  8. Narang, C. K., V. Iyer andN. K. Mathur (1965)Microchem. J. 9, 408.Google Scholar
  9. Schröder, E., andK. Lübke (1965)Methods of Peptide Synthesis, Vol. 1. Acad. Press, New York — London.Google Scholar
  10. Siggia, S., andN. A. Floramo (1953)Anal. Chem. 25, 797.Google Scholar
  11. Simon, W., D. Meuche andE. Heilbronner (1956)Helv. Chim. Acta 39, 295.Google Scholar
  12. Taüfel, K., L. Wagner andW. Z. Preiss (1928)Elektrochemie 34, 283.Google Scholar
  13. Wharton, H. W. (1965)Anal. Chem. 37, 730.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • S. J. Sie-Tjoeng
    • 1
  • H. J. De Jong
    • 1
  1. 1.Department of Pharmaceutical Analysis and Analytical Chemistry, Subfaculty of Pharmacy, Gorleaus LaboratoriaState UniversityLeidenThe Netherlands

Personalised recommendations

Cite article

Buy options