Pharmaceutisch Weekblad

, Volume 2, Issue 1, pp 262–265 | Cite as

Determination of free acid and anhydride content in aliphatic and aromatic cyclic anhydrides by conductometric titration

  • S. J. Sie-Tjoeng
  • H. J. De Jong
Original Articles


The simultaneous determination of free acid and anhydride content in samples of cyclic aliphatic and aromatic anhydrides was studied. Conductometric titration with methanolic sodium methoxide while using acetone as a solvent proves to be a reliable method, applicable to small amounts of sample (0.3 mmol). The results of the conductometric method were checked by potentiometric titration of free acid with trinonylamine, and by determination of the total acid content after complete hydrolysis of the sample.


Sodium Acetone Anhydride Acid Content Reliable Method 
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Copyright information

© Bohn, Scheltema & Holkema 1980

Authors and Affiliations

  • S. J. Sie-Tjoeng
    • 1
  • H. J. De Jong
    • 1
  1. 1.Department of Pharmaceutical Analysis and Analytical Chemistry, Subfaculty of Pharmacy, Gorleaus LaboratoriaState UniversityLeidenThe Netherlands

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