Use of high-performance liquid chromatography in the determination of the radiation stability of hypertensin
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Summary
HPLC was used as a suitable analytical method for the study of radiation and chemical stability of aqueous solutions of the polypeptide hypertensin. Optimum conditions were found for the separation of this substance from its main radiation products. For analysis a chromatographic column packed with the C18 reversed phase and a methanol-acetic acid-ammonium acetate mixture as eluent were used under isocratic conditions.
Key Words
Hypertensin Gamma-radiolytical products HPLC separationPreview
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References
- [1]J. Kopoldová, Ś. Hrnčiř, I. Mezö, J. Labelled Comp. Radiopharm.19, 257 (1982).Google Scholar
- [2]J. R. McDermott, A. I. Smith, J. A. Biggins, M. Chyad Al-Noaemi, J. A. Edwardson, J. Chromatogr.222, 371 (1981).Google Scholar
- [3]J. Rivier, J. Liquid Chromatogr.1, 343 (1978).Google Scholar
- [4]K. Krummen, R. W. Frei, J. Chromatogr.132, 27 (1977).Google Scholar
- [5]M. T. W. Hearn, B. Grego, J. Chromatogr.203, 349 (1981).Google Scholar
- [6]K. E. Bij, C. Horváth, W. R. Melander, A. Nahum, J. Chromatogr.203, 65 (1981).Google Scholar
- [7]A. Nahum, C. Horváth, J. Chromatogr.203, 53 (1981).Google Scholar
- [8]J. A. D. M. Tonnaer, J. Verhoef, V. M. Wiegant, W. De Jong, J. Chromatogr.183, 303 (1980).Google Scholar
- [9]I. Molnár, C. Horváth, J. Chromatogr.142, 623 (1977).Google Scholar
- [10]M. T. W. Hearn, B. Grego, J. Chromatogr.218, 497 (1981).Google Scholar
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© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1983