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Chromatographia

, Volume 33, Issue 9–10, pp 454–462 | Cite as

Evaluation of the enantioselectivity towards β-blocking agents of the α1 glycoprotein type chiral stationary phase: Chiral AGP®glycoprotein type chiral stationary phase: Chiral AGP®

  • C. Vandenbosch
  • T. Hamoir
  • D. L. Massart
  • W. Lindner
Originals

Summary

The enantioselectivity of the α1 glycoprotein chiral stationary phase, Chiral AGP® has been evaluated for a number of β-blocking agents. A correlation has been found between the retention behaviour on this stationary phase and the hydrophobicity of the compounds. The separation factor α is higher for compounds that are well retained. Retention, and thus α, are also controlled by pH and the percentage of organic modifier in the mobile phase.

Key Words

Column liquid chromatography α1 glycoprotein Enantioseparation β-blocking agents 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • C. Vandenbosch
    • 1
  • T. Hamoir
    • 1
  • D. L. Massart
    • 1
  • W. Lindner
    • 2
  1. 1.Pharmaceutical InstituteVrije Universiteit BrusselBrusselsBelgium
  2. 2.Karl-Franzens-Universität GrazGrazInstitute of Pharmaceutical ChemistryAustria

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