Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Headspace analysis of 1,4-dioxane in products containing polyethoxylated surfactants by GC-MS

Summary

A headspace, gas chromatography-mass spectrometric (GC-MS) method for the identification and quantitation of 1,4-dioxane in polyethoxylated surfactants is described. An isotope dilution method employing 1,4-d8-dioxane has been used for the quantitation of 1,4-dioxane which is based on the determination of the molecular ion (mass 88) by MS. The detection limit of the method was 0.3 ppm 1,4-dioxane. 82% of the cosmetic products investigated were found to contain 0.3–96 ppm 1,4-dioxane, and 85% of the products for dish washing investigated contained 1.8–65 ppm 1,4-dioxane.

This is a preview of subscription content, log in to check access.

References

  1. [1]

    T.J. Birkel, C.R. Warner, T. Fazio, J. Assoc. off. Anal. Chem.62, 931 (1979).

  2. [2]

    J.A. Wenninger, Assoc. Food Drug off. U.S.Q. Bull.44, 145 (1980).

  3. [3]

    IARC. International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Human. Vol. 11, 247–256 (1976).

  4. [4]

    IARC. International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Human. Suppl. 7, 201 (1987).

  5. [5]

    National Cancer Institute. NCI Carcinogenicity Technical Report No. NCI-C G-TR-80, Bethesda, MD, 1978.

  6. [6]

    L. Fishbein, Studies in Environmental Science, Vol. 4, “Potential Industrial Carcinogens and Mutagens”, Elsevier, New York, NY, PP 481–486, 1979.

  7. [7]

    I. Lundberg, J. Hogberg, T. Kronevi, B. Holmberg, Cancer Lett.36, 29 (1987).

  8. [8]

    Patty's Industrial Hygiene and Toxicology, (G.D. Clayton, F.E. Clayton eds.) 3rd ed. John Wiley & Sons, Vol. 2C, pp 3947–3956, 1982.

  9. [9]

    A. Fairly, E.C. Linton, A.H. Ford-Moore, J. Hyg. (London)34, 486 (1934).

  10. [10]

    S. Lundberg, Nordiska expertgruppen for grænsevardi-dokumentation, 28. Dioxan I: Arbete och Halsa, p. 6, 1982.

  11. [11]

    D.B. Black, R.C. Lawrence, E.G. Lovering, J.R. Watson, J. Assoc. off. Anal. Chem.66, 180 (1983).

  12. [12]

    J. Rümenapp, J. Hild, Lebensmittelchem. Gerichte. Chem.41, 59 (1987).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rastogi, S.C. Headspace analysis of 1,4-dioxane in products containing polyethoxylated surfactants by GC-MS. Chromatographia 29, 441–445 (1990). https://doi.org/10.1007/BF02261391

Download citation

Key words

  • Gas chromatography-mass spectrometry
  • Headspace analysis
  • Polyethoxylated surfactants
  • 1,4-dioxane